نتایج جستجو برای: amyloid aβ
تعداد نتایج: 40212 فیلتر نتایج به سال:
Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils cause neuronal dysfunction and memory impairment in Alzheimer's disease. These findings suggest that reducing the prevalence of transient intermediates by small molecule-mediated stimulation of amyloid polymeriza...
An early event in Alzheimer's disease (AD) pathogenesis is the formation of extracellular aggregates of amyloid-β peptide (Aβ), thought to be initiated by a prion-like seeding mechanism. However, the molecular nature and location of the Aβ seeds remain rather elusive. Active Aβ seeds are found in crude homogenates of amyloid-laden brains and in the soluble fraction thereof. To analyze the seedi...
Cerebral β-amyloidosis and associated pathologies can be exogenously induced by the intracerebral injection of small amounts of pathogenic Aβ-containing brain extract into young β-amyloid precursor protein (APP) transgenic mice. The probable β-amyloid-inducing factor in the brain extract has been identified as a species of aggregated Aβ that is generated in its most effective conformation or co...
More than 46 million people worldwide suffer from Alzheimer's disease. A large number of potential treatments have been proposed; among these, the inhibition of the aggregation of amyloid β-peptide (Aβ), considered one of the main culprits in Alzheimer's disease. Limitations in monitoring the aggregation of Aβ in cells and tissues restrict the screening of anti-amyloid drugs to in vitro studies...
Background Cerebral beta-amyloid (Aβ) is a hallmark of AD. Few studies have revealed which the regional Aβ markers are associated with abnormal levels status. The aim current study was to identify multivariate predicting positivity (Aβ+). Method Seven hundred and sixty-five participants from ADNI-2 cohort at baseline visit were included in study. We used uptake as predictors predictive model. F...
Previous studies in humans and animals have suggested a possible association between lead (Pb) exposure and the etiology of Alzheimer's disease (AD). Animals acutely exposed to Pb display an over-expressed amyloid precursor protein (APP) and the ensuing accumulation of beta-amyloid (Aβ) in brain extracellular spaces. This study was designed to examine whether in vivo Pb exposure increased brain...
Objective: This study was carried out to investigate the effects of curcumin and resveratrol antioxidant enzymes in β-amyloid (Aβ)-induced vitro Alzheimer's Disease (AD) cell model. Methods: In three groups were created; The control group consisted U87 lines, Aβ which AH model formed including β-amyloid-induced U-87 Aβ+ Curcumin+ Resveratrol by adding group. Cell viability evaluated with 3-(4,5...
Background While cutoffs for abnormal levels of the cerebrospinal fluid (CSF) biomarkers amyloid β 1-42 (Aβ 1-42), total tau (t-tau), phosphorylated (p-tau), and ratios t-tau/Aβ p-tau/Aβ 1-42, have been established in Alzheimer’s disease (AD), biologically relevant not studied extensively Parkinson’s (PD). We aim to assess suitability diagnostic accuracy AD-derived CSF biomarker PD population. ...
The most common isoforms of amyloid-β (Aβ) proteins are composed of 40 or 42 amino acid residues. While Aβ-(1-40) is the predominant species, Aβ-(1-42) is more fibrillogenic and neurotoxic, suggesting that Aβ-(1-42) plays a critical role in the initiation of amyloid fibril formation. We investigated the mechanisms by which soluble Aβ-(1-40) associates with preformed Aβ-(1-42) seeds. A paramagne...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (...
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