نتایج جستجو برای: and ngs
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Recent advances in sequencing technology have allowed researchers to probe the human genome at unprecedented depths. Nextgeneration sequencing (NGS) is rapidly transforming clinical genetics. However, significant barriers remain to the routine adoption of NGS in clinical care. Although NGS has become more affordable—an entire human genome can be sequenced for less than $2000—the bottleneck has ...
Next-generation sequencing (NGS) is increasingly being adopted as the backbone of biomedical research. With the commercialization of various affordable desktop sequencers, NGS will be reached by increasing numbers of cellular and molecular biologists, necessitating community consensus on bioinformatics protocols to tackle the exponential increase in quantity of sequence data. The current resour...
Established and emerging next generation sequencing (NGS)-based technologies allow for genome-wide interrogation of diverse biological processes. However, accessibility of NGS data remains a problem, and few user-friendly resources exist for integrative analysis of NGS data from different sources and experimental techniques. Here, we present Online Resource for Integrative Omics (ORIO; https://...
The development of next-generation sequencing (NGS) technologies for HLA and KIR genotyping is rapidly advancing knowledge of genetic variation of these highly polymorphic loci. NGS genotyping is poised to replace older methods for clinical use, but standard methods for reporting and exchanging these new, high quality genotype data are needed. The Immunogenomic NGS Consortium, a broad collabora...
Next-Generation Sequencing (NGS) has the potential to be the ultimate genotyping platform for human identification. NGS is capable of typing the currently important forensic markers, such as short tandem repeats (STRs), mitochondrial and Y-chromosome haplotypes. Using the same DNA sample, NGS is also capable of typing other polymorphisms including single nucleotide polymorphisms (SNPs) that can...
PURPOSE We evaluated the clinical role of rapid next-generation sequencing (NGS) for identifying BRCA1/2 mutations compared to traditional Sanger sequencing. METHODS Twenty-four paired samples from 12 patients were analyzed in this prospective study to compare the performance of NGS to the Sanger method. Both NGS and Sanger sequencing were performed in 2 different laboratories using blood sam...
Next-generation sequencing (NGS) is a powerful platform for identifying cancer mutations. Routine clinical adoption of NGS requires optimized quality control metrics to ensure accurate results. To assess the robustness of our clinical NGS pipeline, we analyzed the results of 304 solid tumor and hematologic malignancy specimens tested simultaneously by NGS and one or more targeted single-gene te...
Positive detection of minimal residual disease (MRD) by multichannel flow cytometry (MFC) prior to hematopoietic cell transplantation (HCT) of patients with acute lymphoblastic leukemia (ALL) identifies patients at high risk for relapse, but many pre-HCT MFC-MRD negative patients also relapse, and the predictive power MFC-MRD early post-HCT is poor. To test whether the increased sensitivity of ...
Cloud computing implemented in conjunction with next generation communication technologies has brought about many changes in the field that utilizes enormous computing power. Especially in the field of biomedical sciences, the computing environment allows for quick analysis of next-generation sequencing (NGS) data by providing flexible and nearly unlimited computing resources. In cases where da...
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