Objectives: Andrographis paniculata (A. paniculata) is a widely used herb that has potential medical properties. Andrographolide (Andro) is the major component of A. paniculata. We evaluated the anti-tumor activity of Andro using leukemic cell line cells. Methods: Leukemic cell lines U937, HL60 or H929 cells were cultured in the presence or absence of Andro and compared with the effects of Ara-...

Adverse effects and tolerance to dry powder of aerial part of Andrographis paniculata (Burm.f.) Nees were studied in 20 patients with type 2 diabetes mellitus for a period of 12 weeks. Patients were given powdered A. paniculata starting with 600 mg daily, gradually increasing to a maximum of 1.8 gm daily. Parameters monitored included body weight, blood pressure, liver function tests, renal fun...

Andrographis paniculata is a grass-shaped medicinal herb, traditionally used in Southeast Asia. The aim of this study was to evaluate the chemoprotective effects of A. paniculata on colorectal cancer. A. paniculata ethanol extract was tested on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in vivo and in vitro. A. paniculata treated groups showed a significant reduction in the number of ...

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuc...

Andrographis paniculata, "King of bitters" is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon A. paniculata usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of A. paniculata extract and andrographolide (a major phytoactiv...

Antifungal activity assay of the methanol extract of the aerial parts of the plant Andrographis paniculata revealed that it exhibits mycelial growth inhibition of Fusarium solani and spore germination inhibition of Alternaria solani. Pure andrographolide present in the methanol extract also exhibited spore germination inhibition of A. solani. Quantitative estimation of andrographolide in the me...

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, it known that regulate complex responses atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) plant with various pharmacological activities. Andrographolide (AND) main bioactive compound diterpene lactone group. This literature study aims to assess potential AND on proinflammat...

Fresh leaves of Boerhaavia diffusa and Andrographis paniculata were evaluated for nutritional and anti-nutritional compositions. The results showed that both plant leaves contained saponins, alkaloids and flavonoids. The proximate analysis and vitamin C of B. diffusa and A. paniculata included moisture (76.04% and 73.02%), carbohydrate (17.14% and 12.16%) and vitamin C (40.00 and 45.01mg/100g),...

BACKGROUND Renal failure is an increasingly common condition with limited treatment options that is causing a major financial and emotional burden on the community. Andrographis paniculata is the plant used in Ayurveda for several remedies. Scientific evidence suggests its versatile biological functions that support its traditional use in the Orient. The plant is claimed to possess immunologica...

Tumbuhan Andrographis paniculata menghasilkan beragam metabolit sekunder yang memiliki berbagai aktivitas biologis termasuk antibakteri. Senyawa antibakteri pada tumbuhan ini juga dapat diekplorasi dari jamur endofitik berasosiasi dengan A. paniculata. Penelitian bertujuan untuk mengetahui RS-1 ranting menggunakan media beras hitam. Tahapan penelitian terdiri isolasi, kultivasi, ekstraksi, uji ...