Hydrogel Scaffolds In article number 2102837, Yongxiang Luo, Peng Huang, Jinwu Wang, and co-workers present a method for inducing controlled tumor angiogenesis by engineering the microenvironment. The interstitial flow direction regulates of capillary sprouting, while existence lung fibroblasts affects continuity lumen formation sprouted capillaries. vascularized model shows enhanced delivery a...

Concomitant tumour resistance (CTR) is a unique phenomenon in which animals harbouring large primary tumours are resistant to the growth of smaller metastatic tumours by systemic angiogenic suppression. To examine this clinically, in ten patients with osteosarcoma, we investigated the effects of removal of the primary tumour on the development of pulmonary metastases, the systemic angiogenesis-...

A 47-year-old man presented with intussusception of the colon and was found to have a large tubulo-villous adenoma high grade dysplasia, transforming into adenocarcinoma. The bowel adjacent polyp showed florid vascualr proliferation, mimicking vascular neoplasm. However, there were no signs atypia or malignancy in lesion. We illustrate an example chronic obstruction inducing hypoxia, leading ne...

Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response. The chemokine family characterized by four highly conserved cysteine amino acid residues, ...

In this study, we review the synthesis of copper nanoparticles (CuNPs) and their prospective uses as antioxidants, antimicrobials, anticancer agents in pharmaceutical sector. Copper could be created through a variety methods, including chemical reduction, green synthesis, physical electrochemical deposition, microemulsion method. These methods make it possible to precisely create with necessary...

Broadly speaking, MR imaging techniques can be divided into two groups: those that use extrinsic contrast agents and those that do not. Contrast-enhanced methods for imaging angiogenesis: • Dynamic contrast-enhanced (DCE) MRI using low molecular weight agents (<1,000 Daltons) that rapidly diffuse in the extracellular fluid space (ECF agents) • DCE-MRI using large-molecular agents (>30,000 Dalto...

Genetic experiments (loss-of-function and gain-of-function) have established the role of Angiopoietin/Tie ligand/receptor tyrosine kinase system as a regulator of vessel maturation and quiescence. Angiopoietin-2 (Ang-2) acts on Tie2-expressing resting endothelial cells as an antagonistic ligand to negatively interfere with the vessel stabilizing effects of constitutive Ang-1/Tie-2 signaling. An...