A structure-activity relationship study was attempted to determine the structural specificity of the no. 8 amino acid residue of [l-asp.,5-ileu]angiotensin II for adrenal medullary stimulation. Isolated cat adrenal glands were perfused retrograde at a flow rate of 1 ml/min with phosphate-buSered Locke's solution at 23 to 25 C, Continuous catecholamine analysis was performed using an automated t...

Angiotensin II stimulates prostaglandin release in blood vessels via activation of angiotensin receptors present in endothelium, vascular smooth muscle cells, or both. We evaluated the response of angiotensin II, angiotensin I, and [des-Phe8] angiotensin II [angiotensin-(1-7)] on prostaglandin release in porcine aortic endothelial cells. Incubation of cell monolayers with angiotensin I and angi...

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...

Objective(s): Considering the lack of information, the effects of mild endurance exercise plus blood flow restriction (BFR) on electrocardiographic parameters, hypertrophy index, and expression of angiotensin II receptors type 1 (AT1R) and type 2 (AT2R) and apelin receptor (APJ) were assessed in hearts of old male rats.Materials and Methods: Animal were grouped as control (CTL), Sham (Sh), lowe...

      Losartan potassium is a well known orally active non-peptide angiotensin II receptor antagonist. Losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptors. The drug is reported to promote the decrease in ventricular hypertrophy, salt ...

Submit Manuscript | http://medcraveonline.com Abbreviations: RAS, renin angiotensin system; IPF, idiopathic pulmonary fibrosis; HCV, hepatitis c virus; BPD, bronchopulmonary dysplasia; ECM, extracellular matrix; ACE, angiotensin converting enzyme; ACE-2, angiotensin converting enzyme 2; Ang I, angiotensin I; Ang II, angiotensin II; Ang 1-7, angiotensin 1-7; AT1, angiotensin II receptor 1; AT2, ...

OBJECTIVE The objective of this study was to investigate ACE- and chymase-dependent angiotensin I-to-II conversion in human coronary arteries (HCAs). METHODS AND RESULTS HCA rings were mounted in organ baths, and concentration-response curves to angiotensin II, angiotensin I, and the chymase-specific substrate Pro(11)-D-Ala(12)-angiotensin I (PA-angiotensin I) were constructed. All angiotensi...

The aim of this study was to determine whether angiotensin receptor subtypes play a role in angiotensin clearance from plasma. Angiotensin metabolic clearance rate was measured in rats by the constant infusion method. Increasing doses of angiotensin II were infused for 15 minutes, and blood was sampled for angiotensin II. The type 1 angiotensin II receptor antagonist losartan decreased the appa...