نتایج جستجو برای: angiotensins
تعداد نتایج: 23319 فیلتر نتایج به سال:
Mice lacking Ren1c were generated using C57BL/6-derived embryonic stem cells. Mice homozygous for Ren1c disruption (Ren1c-/-) are born at the expected ratio, but approximately 80% die of dehydration within a few days. The surviving Ren1c-/- mice have no renin mRNA expression in the kidney, hydronephrosis, thickening of renal arterial walls, and fibrosis in the kidney. Plasma renin and angiotens...
Renin and angiotensins coexist in various tissues. The mode of control of the extrarenal renin-angiotensin system is not clear. Whether it is renin or angiotensin that is secreted has not been identified. We have investigated gonadotropin-dependent synthesis and subsequent release of the components of the intracellular renin-angiotensin system in a cloned and cultured mouse Leydig tumor cell li...
P Goldblatt's experiments on renal arteries (1934) had resulted in the first animal model of chronic hypertension. In 1954, Leonard Skeggs first described existence of renin and two forms of peptide "hypertensins" and a converting enzyme and in the serum of the horse blood. By 1958, hypertensin and angiotonin were uniformly designated angiotensins. During the 60s, numerous group of researchers ...
The cleavage of synthetic tetradecapeptide renin substrate has been used to infer the presence of renin in the walls of isolated blood vessels; however, the conversion of natural angiotensinogen to angiotensin in isolated blood vessels has not been reported. We studied the release of angiotensinogen and the formation of angiotensins in a bloodless, perfused, isolated hind limb preparation of th...
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