INTRODUCTION Although the government of Yemen changed the national policy for treating malaria in November 2005 from chloroquine to combination drugs in the form of artesunate + sulphadoxine-pyrimethamine (SP) as first line and lumefantrine + artemether as second line treatment for uncomplicated malaria, clinicians in public and private health facilities continued to prescribe chloroquine becau...

Malaria parasites were identified by Laveran in Algeria in 1883, their cycle largely elucidated by Ross in India in 1895 and transmission of malaria by Anopheles was identified by Grassi in Italy in 1899. Very soon after the transmission of malaria had been elucidated, the first science-based approaches to preventing the disease were designed and implemented by Celli in Italy. Italy had had a t...

The number of people travelling to malaria-endemic countries continues to increase, and malaria remains the commonest cause of serious imported infection in non-endemic areas. Severe malaria, mostly caused by Plasmodium falciparum, often requires intensive care unit (ICU) admission and can be complicated by cerebral malaria, respiratory distress, acute kidney injury, bleeding complications, and...

Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria. However, almost all the fatalities are due to Plasmodium falciparum, a species responsible for the severest cases including cerebral malaria. Immune response to Plasmodium falciparum infection is...

malaria is a parasitic disease that is starting to be encountered in intensive care units (icu) worldwide, owing to increasing globalisation. severe malaria caused by plasmodium falciparum , is characterised by cerebral malaria, acute renal failure, hypoglycaemia, severe anaemia, splenomegaly and alveolar oedema. we present the case of a 25-yr old male patient who presented to the emergency dep...

Malaria is a potentially fatal disease caused by protozoan parasites of the genus Plasmodium. It responsible for significant morbidity and mortality in endemic countries tropical subtropical world, particularly Africa, Southeast Asia, South America. estimated that 247 million malaria cases 619,000 deaths occurred 2021 alone. The World Health Organization’s (WHO) global initiative aims to reduce...

BACKGROUND Lung cancer is the most common malignancy in humans and its high fatality means that no effective treatment is available. Developing new therapeutic strategies for lung cancer is urgently needed. Malaria has been reported to stimulate host immune responses, which are believed to be efficacious for combating some clinical cancers. This study is aimed to provide evidence that malaria p...

The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body t...

A number of studies have shown that CD8+ T cells mediate protective anti-malaria immunity in a mouse model. However, whether human CD8+ T cells play a role in protection against malaria remains unknown. We recently established human immune system (HIS) mice harboring functional human CD8+ T cells (HIS-CD8 mice) by transduction with HLA-A∗0201 and certain human cytokines using recombinant adeno-...