INTRODUCTION The development of anti-D antibodies results from foetomaternal sensitisation occurring in rhesus (Rh) negative blood group women who carry an Rh-positive foetus. Despite guidelines on Rh immunoprophylaxis, isoimmunisation continues to occur, suggesting that the guidelines are not being fully applied by obstetricians. This study aims to establish the adequacy of knowledge on Rh imm...

A patient with warm autoimmune hemolytic anemia (AIHA) due to predominance of immunoglobulin A (IgA) with an Rh specificity, considered to be the first case in Korea, is described. A 13-year-old male patient with severe hemolytic anemia showed a weak reactivity (1+) in the direct antiglobulin test (DAT) by using anti-IgG antiglobulin reagent. This finding, however, could not fully explain the p...

Observations are described of the incidence among Caucasians and Negroes of the blood factors Rh(A), Rh(B) and Rh(C) which occur associated with the Rh(0) factor in typical Rh-positive blood. The antiserums used for the tests were derived from Rh-positive patients who had had hemolytic transfusion reactions or erythroblastotic babies. Among a large series of individuals, it was found that only ...

Maternal-fetal ABO incompatibility is a common hematological problem affecting the newborn. In general, hemolysis is minimal and the clinical course is relatively benign, rarely causing the escalating levels of hyperbilirubinemia and significant anemia commonly associated with Rh hemolytic disease of the newborn (HDN). The incidence of HDN ranges from one in 150 births to 1:3000 births, dependi...

Of 655 Rh negative women without anti-D antibody in their serum at genetic amniocentesis, 361 delivered a Rh positive infant. Prophylactic treatment with anti-D immunoglobulin was not given at amniocentesis. The women were followed prospectively, being given a screening test for antibody after amniocentesis, at delivery, and six months later. Five of these 361 women yielded a positive test resu...

Understanding anti-Rh(D) antibodies on a molecular level would facilitate the genetic analysis of the human immune response to Rh(D), lead to the design of therapeutically useful reagents that modulate antibody binding, and provide relevant information regarding the structural organization of Rh(D) epitopes. Previously, we described a Fab/phage display-based method for producing a large array o...

OBJECTIVE To provide guidelines on use of anti-D prophylaxis to optimize prevention of rhesus (Rh) alloimmunization in Canadian women. OUTCOMES Decreased incidence of Rh alloimmunization and minimized practice variation with regards to immunoprophylaxis strategies. EVIDENCE The Cochrane Library and MEDLINE were searched for English-language articles from 1968 to 2001, relating to the preven...

background: serological diagnosis of toxoplasma gondii infection using crude antigens may not be more accurate. to increase the diagnostic potency of anti-gens, isolation of their immunogenic fractions could be useful. the current re-search adopted to obtain an affinity isolated fraction from rh strain using cnbr sepharose 4b column coupled with infected mice sera helping in detec-tion of igm a...

Transfusion of one unit or more of Rh-positive red blood cells normally causes circulating anti-D antibody to appear 2-6 months later in 80-95% of Rh- persons. We asked whether transplant immunosuppression with cyclosporine and corticosteroids affects Rh immunization. Nineteen Rh- liver, heart, and heart-lung transplant recipients received 3-153 (median: 10) units of Rh+ RBCs at surgery and wer...

DURING the past decade there has been a dramatic fall in the incidence and mortality from Rh haemolytic disease (Tovey 1976; Magee, lIarley, Campbell and McClure, 1969-78). This is due to two factors, firstly the appreciable fall in the number of Rh (D) negative women having babies, particularly if they had developed Rh antibodies previously; and secondly the routine administration of anti-D im...