A 9-year-old boy received a rifampicin-isoniazid-ethambutol regimen for suspected extra-pulmonary tuberculosis, and glucurolactone and vitamin B6 to provide liver protection and decrease neurotoxicity associated with isoniazid. Baseline serum aminotransferase and total bilirubin levels were within normal limits before anti-tubercular treatment. After 4 days of treatment, the patient's body temp...

we report a case of a 68-year-old female who was a known case of diabetes mellitus and chronic liver disease and presented with complaints of dry cough and other constitutional symptoms since one month. during initial investigations, the patient was found to have peripheral blood eosinophilia. upon investigating further,the patient was found to have mediastinal lymphadenopathy and fine-needle a...

a 25-year-old female presented to the infertility opd with complaints of secondary infertility and pain lower abdomen with watery discharge for the past five days. she had history of undergoing hysterosalpingography in a private hospital ten days back. the interventions included drainage of pyometra, endometrial biopsy for routine and afb smear/ culture,  confirmation of diagnosis by m rna-base...

A quantitative structure activity relationship study was performed on different groups of anti-tuberculosis drug compound for establishing quantitative relationship between biological activity and their physicochemical /structural properties. In recent years, a large number of herbal drugs are promoted in treatment of tuberculosis especially due to the emergence of MDR (multi drug resistance) a...

Introduction: Tuberculosis is a communicable disease caused by mycobacterium tuberculosis that primarily affects the lungs. Primary tuberculosis of the nose in the pediatric age group is rare. The diagnosis of this common entity in the present case was challenging.   Case Report: We report the case of a 3-year old girl who presented with a painless swelling over the dorsum of the nose for 7 mon...

Anti tubercular drug related hepatotoxicity is common. The mechanism of injury and factors predisposing to its development are not fully understood. Forty patients with anti tubercular drugs related hepatotoxicity were studied to see the clinical and biochemical profile of these patients and to find out the significance of acetylator phenotype in the development of hepatotoxicity. Mean age of p...

Causality Assessment of Suspected Adverse Drug Reaction with Anti-Tubercular Therapy by WHO Probability ScaleS. Yadav, K.K. Pillai, P. Kapur

Allium sativum has been reported to have a lot of therapeutic potentials such as antihypertensive, antimicrobial and hypocholesterolemic. This study has investigated its effect on anti-tubercular drugs hepatotoxicity. Wistar albino rats were pretreated and co-administered orally with aqueous solution of Allium sativum. Eighteen rats were divided into six groups of three rats each. Group 1 were ...

The medications used to treat HIV and TB can result in significant adverse effects and drug interactions which can adversely impact the disease management. The objective of this study is to determine the adverse reactions to anti-tubercular drugs in these HIV/TB co-infected patients. A retrospective study of case record files of HIV/TB co-infected patients on anti-tubercular treatment was carri...

The use of anti-tubercular therapy (ATT) along with anti-retroviral therapy (ART) in human immunodeficiency virus-tuberculosis (HIV-TB) co-infected individuals could at times lead to paradoxical worsening due to an increase in the inflammatory activity due to immune reconstitution inflammatory syndrome (IRIS) in the eye. This is characterized by anterior and posterior segment inflammatory react...