layer of the dermis and is the major cellular component responsible for skin color. Although normal melanin pigmentation in the skin is the major defense mechanism against ultraviolet light, the production of abnormal pigmentation such as melasma, freckles, senile lentigines, and other forms of melanin hyperpigmentation can be a serious problem aesthetically. The novo synthesis of melanin invol...

objective(s): in food industry, the inhibition of tyrosinase is very important, because this enzyme catalyzes the oxidation of phenolic compounds found in fruits and vegetables into quinones, which contribute in undesirable color and taste of fruits and vegetables. teucrium polium l. var. gnaphalodes (lamiaceae), a wild-growing flowering plant that has many applications in food preparations and...

The psychosocial burden akin to cutaneous conditions such as cancer and hyperpigmentation disorders, make their management very sensitive. Current therapeutic interventions, are associated with side-effects, cost, invasiveness bioavailability issues. Herein, 26 new pyrazole pyrazolone compounds were synthesized via microwave-assisted reactions pharmacokinetic parameters ADMET predicted by in-si...

In this work, a series of anti-tyrosinase and anti-butyrylcholinesterase coumarin derivatives 4a–f 5a–f were synthesized starting from 4-hydroxycoumarin. The condensation 2-(arylimin)-4-hydroxycoumarins 3a–f with dimethylformamide dimethyl acetal (DMF-DMA), used as key reaction, afforded the precursors 4a–f, whose acid treatment led to formation 5a–f. These prepared heterocycles characterized b...

Functional foods to prevent aging, particularly skin have grown in popularity as society ages and science uncovers the pathological mechanisms of aging. In this study, we used processed ginseng, one famous functional foods, along with fermentation utilizing novel Aspergillus niger strain KHNT-1 enhance its value efficacy. We successfully produced fermented black ginseng (FBG) investigated anti-...

BACKGROUND The aim of this study was to determine the presence and the intensity of humoral immunity to melanoma-associated antigens: tyrosinase and melanin, in patients with melanoma, in persons with vitiligo and in control healthy people. METHODS The study involved 63 patients with melanoma and 19 persons with vitiligo. Control group consisted up to 41 healthy volunteers. Mushroom tyrosinas...

The aims of this study were to induce calli from the seeds three rice varieties (Hommali 105, Munpu, and Niawdum) investigate their anti-aging potential. First, cultured on a Murashige Skoog medium (MS medium) supplemented with 2 mg/L 2,4-Dichlorophenoxyacetic acid (2,4-D), 1 1-Naphthalene acetic (NAA), 6-Benzylaminopurine (BAP). After weeks, extracted ethanol. Then, phenolic contents determine...

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

In the present study, new Schiff's base derivatives: (Z)-4-amino-5-(2-(3- fluorobenzylidene)hydrazinyl)-4H-1,2,4-triazole-3-thiol (Y1), (Z)-3-((2-(4-amino-5- mercapto-4H-1,2,4-triazol-3-yl)hydrazono)methyl)phenol (Y2), (Z)-2-((2-(4-amino-5- mercapto-4H-1,2,4-triazol-3-yl)hydrazono)methyl)phenol (Y3) and 3-((Z)-(2-(4- (((E)-3-hydroxybenzylidene)amino)-5-mercapto-4H-1,2,4-triazol-3-yl)hydrazono)m...

OBJECTIVES In previous studies, antioxidant activity of Viola odorata L. has been demonstrated. In this study, we have investigated the anti-melanogenic effect of extract and fractions of the plant in B16F10 cell line. MATERIALS AND METHODS Impact of different increasing concentrations of extract and fractions of V. odorata was evaluated on cell viability, cellular tyrosinase, melanin content...