BACKGROUND Septic arthritis is a severe and rapidly debilitating disease mainly caused by Staphylococcus aureus. Here, we assess the antiarthritic efficiency of glutaminyl cyclase (QC) inhibitors. METHODS Mice were inoculated with an arthritogenic amount of S. aureus intravenously or by local administration into the knee joint. Animals were treated with QC inhibitors (PBD155 and PQ529) via ch...

Background & Aim: Allium sativum commonly known as garlic is an herb used over years to prevent from various ailments such as cardiovascular diseases, cognitive disorders and also enhances the immune system. The aim of the present study is to study the in vitro antiarthritic and antihemolytic potential of garlic in aqueous and methanolic extracts. Fourier tran...

The novel bicyclo thieno 1, 2, 3-triazines (BTT) namely BTT-1, BTT-2, BTT-3 and BTT-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. Analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (CFA) induced arthritis model was used for anti...