AbstractPyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

The antibacterial and anti-biofilm activity of ethanolic extract from the rhizome of Zingiber officinale were evaluated. In vitro antibacterial activity was investigated by microdilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined. The values were in the range from 0.0024 to > 20 mg/ml. The most sensitive bacteria were Gram-po...

Objective To assess the application of antibacterial agents, alongside pathogen prevalence and Pseudomonas aeruginosa drug resistance, with the aim of understanding the impact of inappropriate antibacterial use. Methods This retrospective study assessed bacteria from wounds, catheters, blood, faeces, urine and sputum of hospitalized patients in burn wards between 2007 and 2014. The intensity of...

Silver nanoparticles (AgNPs) have been used as antibacterial, antifungal, antiviral, anti-inflammtory, and antiangiogenic due to its unique properties such as physical, chemical, and biological properties. The present study was aimed to investigate antibacterial and anti-biofilm activities of silver nanoparticles alone and in combination with conventional antibiotics against various human patho...

It has been postulated that the development of resistance to known anti-bacterials could be overcome by identifying new drugs. Hence, the objective of the work is to improve upon the existing anti-bacterial activity of the herbal drug molecule. The main purpose is to synthesize and characterize herbo-mineral complexes and evaluate them for antibacterial activity. This research study deals with ...

In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (...

The present study was aimed to screen the anti-bacterial properties of medicinally important ferns viz., Adiantum caudatum L., Adiantum latifolium Lam. and Adiantum lunulatum Burm against the selected UTI pathogens. Anti-bacterial study was carried out by disc diffusion method against the pathogens viz., Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus maximum degree of antibac...

From the Hematology-Oncology Division, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 021 I1, the *Department of Pathology, New York University, New York, 10016, the *Department of Biochemistry and Pharmacology, Tufts University School of Medicine, and the ~Departments of Microbiology, Human Genetics and Development, and Neurology,...

AbstractPyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...