Staphylococcus aureus is a human pathogen responsible for most wound and hospital-acquired infections. The protein MgrA is both an important virulence determinant during infection and a regulator of antibiotic resistance in S. aureus. The crystal structure of the MgrA homodimer, solved at 2.86 A, indicates the presence of a unique cysteine residue located at the interface of the protein dimer. ...

Graphical Abstract The antimicrobial mode of action brevicidines. Brevicidines are potent cyclic lipopeptides active against Gram-negative pathogens. They have low hemolytic activity and cytotoxicity. BrevicidineB, a single amino acid residue mutant brevicidine, displays an altered spectrum, showing also Gram-positive Due to disruption the proton motive force pathogens, brevicidines act as bact...

We find that the minimum distance of the binary [137; 69] quadratic residue code is 21.

The highest frequency is on day 1 (after treatment) after which it gradually decreases. It should be noted that no antibiotic residues were detected in the collected milk samples prior to treatment. Antibiotic may of recently calved animals due intramammary treatments during dry period (chronic mastitis). If treatment less than 15 days until calving, detecting calving high. As noted, there two ...