Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by reduced activity of the C1 esterase inhibitor. Clinically, angioedema most often involves the upper extremities, face, neck and larynx. The most common cause of death is asphyxia related to laryngeal oedema. Attacks are triggered by many factors such as trauma, stress, infections and hormonal fluctuations. C1 esterase i...

Spontaneous disappearance of an intracranial aneurysm after subarachnoid hemorrhage is an uncommon event and usually associated with severe cerebral vasospasm, giant aneurysms or the use of antifibrinolytics. We present a young woman who suffered a grade 5 subarachnoid hemorrhage with severe vasospasm caused by a small anterior communicating artery aneurysm. The patient underwent a slow recover...

Background: Hereditary angioedema (HAE) is a rare disease characterized by recurrent, self-limiting attacks of subcutaneous and submucosal edema. Though a majority of patients will experience symptom onset before 20 years of age, there is a paucity of published literature regarding the management of HAE in children and adolescents. Methods: A comprehensive literature review regarding the manage...

Evaluation and management of trauma-induced coagulopathy has seen significant advances in the 21st century. Massive transfusion strategies favoring 1:1:1 ratios blood components1 or whole transfusion2 have increasingly become standard. Coagulopathy prediction tools3 viscoelastic hemostatic assays to quantify derangements4,5 are used anticipate guide therapies respectively. A focus on treating h...

Background: Hereditary angioedema (HAE) is a rare disease characterized by recurrent, self-limiting attacks of subcutaneous and submucosal edema. Though a majority of patients will experience symptom onset before 20 years of age, there is a paucity of published literature regarding the management of HAE in children and adolescents. Methods: A comprehensive literature review regarding the manage...