In this study, antifungal property of olive leaf extracts against Candida albicans PTCC-5027 was examined. Fresh olive leaf extracts were prepared using distilled water in a Soxhlet apparatus. The antifungal activity of the extract was analyzed by measuring the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), using the microdilution test and disc diffusion assa...

OBJECTIVES Fungi have been suspected of contributing to the pathogenesis of sarcoidosis. A previous intervention study demonstrated an improvement in the clinical condition in 15 out of 18 patients with a long-term history of sarcoidosis when antifungal medication was added to corticosteroids. The present study was performed to compare the effects of antifungal treatment with corticosteroid tre...

Skin infection caused by Tricophyton rubrum and some opportunistic fungi such as Candida. Albicance and Aspergillus. fumigatus occur in various parts of the body and sometimes are difficult to be treated. Antifungal effects of spherical silver nanoparticles (nano-Ag) were investigated in this study. Although silver nanoparticle has long been used as effective inorganic antifungal agent; the ant...

In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on ...

Search for naturally occurring compounds with antifungal activity has become quite intense due to the side effects of synthetic fungicides and the development of pathogens against such fungicides. Hence screening of various Siddha drugs for their antifungal activity against various strains of Candida albicans was considered worthwhile. Seven such Siddha drugs were screened for their antifungal ...

  Objective: In order to use natural compounds in controlling plant pests and diseases, many researchers in recent years have studied the antifungal effects of essential oils and plant extracts.  The purpose of this study was to investigate the chemical composition and antifungal effects of Echium khuzestanium and marubbium anisodan extract...

EVALUATION OF ANTIFUNGAL, ANTIBACTERIAL AND CYTOTOXIC EFFECTS SOME NEW DERIVATIVES SPIROOXYINDOLES

dermatophyte fungi are the etiologic agents of skin infections commonly referred to as ringworm. these infections are not dangerous but as a chronic cutaneous infections they may be difficult to treat and can also cause physical discomfort for patients. they are considered important as a public health problem as well. no information is available regarding the efficacy of antifungal agents again...

We found that amiodarone has potent antifungal activity against a broad range of fungi, potentially defining a new class of antimycotics. Investigations into its molecular mechanisms showed amiodarone mobilized intracellular Ca2+, which is thought to be an important antifungal characteristic of its fungicidal activity. Amiodarone is a synthetic drug based on the benzofuran ring system, which is...