Two antimicrobial metabolites were isolated from submerged cultures of Cladobotryum rubrobrunnescens, a mycophilic fungus growing on a Inocybe species. One of the compounds proved to be identical to flavipucine (2), an antibiotic previously isolated from Aspergillus flavipes (Casinovi et al., 1968) and from a Macrophoma species (Sassa T. and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). T...

An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The activity was excreted into the supernatant during the log and early stationary phase. When the organism was fermented in the presence of the adsorber resin XAD-16, the metabolite was quantitatively bound to the resin. The main component, jerangolid A, has structural similari...

Fungal co-cultivation has emerged as a promising way for activating cryptic biosynthetic pathways and discovering novel antimicrobial metabolites. For the success of such studies, a key element remains the development of standardized co-cultivation methods compatible with high-throughput analytical procedures. To efficiently highlight induction processes, it is crucial to acquire a holistic vie...

Flavipin, a metabolite produced by Aspergillus species is potent antibiotic, antifungal, anticancer, and nematocidal agent. The present study was conducted to investigate the cytotoxicity antimicrobial activity of flavipin flavus. Eighty isolates were screened for presence flavipin. Macroscopic, microscopic, molecular characterizations performed identify species. Flavipin extract prepared, frac...

Abstract A study of antifungal properties violacein-forming strain Janthinobacterium sp. B-3515 as well its secondary metabolite, violacein, against Alternaria brassicicola F-1864 is presented. Regardless the presence bacteria, mycelium growth in first two days proceeded at same rate. The effect bacterial was manifested after third day incubation. In general, during co-culture, statistically si...

Research on natural products from marine algae has increased dramatically since last few decades. Marine natural products provide a rich source of chemically diverse compounds which have significant potential to be developed as novel types of therapeutic agents. Certain marine products diverse in biological and therapeutic potential have been found to exhibit significant antimicrobial effects a...

Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of 1 to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (2) show potent ...