Incessant malaria endemicity in the tropics and subtropical regions and the recent work done on the synthesis of metal drug complexes of antimalarial drugs and the evaluation of their antimalarial activities in vitro, has led to the development of this study. Quinine-Zinc complex (QZ) was synthesized using a modification of Singla and Wadhwa method. Melting point determination, TLC analysis, in...

Quaternary ammonium compounds have received recent attention due to their potent in vivo antimalarial activity based on their ability to inhibit de novo phosphatidylcholine synthesis. Here we show that in addition to this, heme binding significantly contributes to the antimalarial activity of these compounds. For the study, we used a recently synthesized bis-quaternary ammonium compound, T16 (1...

Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...

Background Currently, antimalarial drug resistance poses a serious challenge. This stresses the need for newer antimalarial compounds. Carica papaya is used traditionally and showed in vitro antimalarial activity. This study attempted to evaluate in vivo antimalarial activity of C. papaya in mice. Methods In vivo antimalarial activity of solvent fractions of the plant was carried out against ...

The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis an...

A large number of piperidyl quinolinemethanols were investigated for antimalarial activity in avian infections because of close chemical similarity to quinine, as part of the wartime search for new and more effective antimalarial agents. In preliminary observations, SN-10,275,3 or 6,8-dichloro-2phenyl-a-2-piperidyl4-quinolinemethanol (Figure 1), gave greatest indication of promise. It is a comp...

The leaf, root, and stem extracts of Brucea javanica were screened for phytochemical properties and antimalarial activity, after extractions with various organic solvents. Qualitative analysis of the phytochemical constituents showed the presence of the following secondary metabolites: terpenoids, saponins, flavonoids, steroids, phenols, glycosides, alkaloids, and anthraquinones. The extracts s...

Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.

Terrestrial plants have been demonstrated to be sources of antimalarial compounds. In Cuba, little is known about antimalarial potentials of plant species used as medicinals. For that reason, we evaluated the antimalarial activity of 14 plant species used in Cuba as antimalarial, antipyretic and/or antiparasitic. Hydroalcoholic extracts were prepared and tested in vitro for the antimalarial act...

OBJECTIVE To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. METHOD Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. RESULTS DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum ...