We report on two patients with Ph+ chronic myeloid leukemia (CML) in chronic phase who developed severe thrombocytopenia during treatment with interferon-alpha 2A (IFN-alpha 2A). In both cases, we detected the presence of platelet-associated antibodies (PAIg) by autoimmune flow cytometry. We postulated an immune mediated platelet destruction mechanism; corticosteroid therapy was employed and in...

Niclosamide, an anthelmintic drug approved by the US Food and Drug Administration against cestodes, is used to treat tapeworm infection. In this study, we show that niclosamide can potentially inhibit signal transducer and activator of transcription 3 (STAT3) in colon cancer cell lines. Combined inhibition of epidermal growth factor receptor and STAT3 by erlotinib and niclosamide synergisticall...

Four new sulfated sesquiterpene hydroquinones siphonodictyals E1-E4 (1-4) and cyclosiphonodictyol A (5) were isolated from a sample of the Caribbean sponge Aka coralliphagum collected off the coast of San Salvador in the Bahamas. The structures of the new compounds were elucidated on the basis of mass spectrometric and NMR spectroscopic analysis. Compounds 1-4 are derivatives of siphonodictyal ...

A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most these compounds showed antiproliferation activities several human cancer cell lines exhibited inhibition efficacy against the estimated glomerular filtration rate (EGFR) in nanomolar level. Among those compounds, compound B5 (also named SIPI6473) displayed maximum effect, thus was...

The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures we...

Chalcones, which have characteristic 1,3-diaryl-2-propen-1-one skeleton, are mainly produced in roots, rhizomes, heartwood, leaves, and seeds of genera Angelica, Sophora, Glycyrrhiza, Humulus, Scutellaria, Parartocarpus, Ficus, Dorstenia, Morus, Artocarpus, and so forth. They have become of interest in the research and development of natural antitumor agents over the past decades due to their b...

Abstract A series of novel 4,6-dimorpholinyl-1,3,5-triazine derivatives 6a–6r were obtained through N -substitution and Claisen-Schmidt condensation. 1 H NMR, 13 C mass spectrometry used to characterize the molecular structures derivatives. The in vitro antiproliferation activity was evaluated using MTT assay against SW620 (human colon cancer cells), A549 nonsmall cell lung HeLa cervical MCF-7 ...

A simple and inexpensive, single step synthesis of silver nanoparticles was achieved using sodium citrate both as a reducing and capping agent. Silver nanoparticles were synthesized by injecting sodium citrate solution into the solution of silver nitrate at high temperature. The synthetic process was carried out in aqueous solution, making the method versatile and ecofriendly. The synthesized s...