Psoriasis is a chronic inflammatory skin disease with hyperproliferation and aberrant differentiation of keratinocytes in association the elevation interleukin-17A (IL-17A) IL-23 levels. In an animal model, psoriasis-like dermatitis was induced on shaved dorsal BALB/c mice by topical application imiquimod (IMQ), synthetic ligand Toll-like receptor 7. Administration bitter Pu’er tea significantl...

The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of 1,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described. The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in ...

Prolactin possibly plays a pathogenetic role in psoriasis by stimulating keratinocyte proliferation, T-lymphocyte interferon gamma production and promoting angiogenesis1. The inhibition of the T-suppressor cell functions by prolactin may serve to promote psoriatic plaque development2. It has been postulated that retinoids decrease the prolactin secretion from pituitary gland and add to their an...

Leishmaniasis represents a complex, globally widespread opportunistic infection ranging from the visceral form, also called kala-azar, to the mucocutaneous and cutaneous disease. It is endemic in the Mediterranian Basin, Leishmania infantum being demonstrated as the main causative agent of autochthonous cases in Sicily, Italy. The long-term use of systemic antipsoriatic agents, including biotec...