Objective: Shortia and other members of the Diapensiaceae family have ethnomedicinal history in both Eastern and Western hemispheres. Based on ethnopharmacological and chemosystematic evidence, pharmacological and toxicological bioassays were conducted on the rare plant Oconee Bell, Shortia galacifolia. Materials and Methods: Extracts were examined in assays for antimutagenicity, antitumor and ...

Paris polyphylla Smith var. yunnanensis, has been used in traditional Chinese medicine for its antibiotic and anti-inflammatory properties; in addition it has been used to cure liver cancer in particular. In this current study, β-ecdysterone (1) and three pennogenin steroidal saponins (2-4) were isolated from the EtOH extract of Paris polyphylla var. yunnanensis, and then tested for their antit...

Antitumor effect of cytogenin against IMC carcinoma in mice was investigated. Since cytogenin did not show cytotoxicity against tumor cells in vitro at 50 micrograms/ml and toxicity at more than 2,000 mg/kg i.p., it was considered that the antitumor effect is due to host mediated events. Cytogenin showed antitumor activity against a syngeneic murine transplantable tumor, IMC carcinoma by oral a...

established by the National Cancer Institute'). Kijanimicin, which is water soluble, was dissolved in saline and injected intraperitoneally into tumor bearing mice according to the schedules shown on the accompanying tables. The results of a test in which kijanimicin was administered on three different dose schedules to mice bearing P-388 leukemia are shown in Table 1. The maximum survival incr...

Introduction Bone metastases are a major cause of morbidity for patients with many types of cancer including multiple myeloma, breast cancer, prostate cancer, and other solid tumors. The clinical complications of bone metastases include pain, fracture, spinal cord compression, and hypercalcemia of malignancy. Although there are important differences in the biology of bone metastases from differ...

IL-6 has been recently cloned and expressed by recombinant DNA techniques in Escherichia coli (1-3) . It is a 19-30-kD phosphoglycoprotein that can elicit a broad range of immune and acute phase responses. IL-6 can act as a cytotoxicT cell differentiation factor as well as astimulatory factor forT cells and B cells (4-6). Stimulation ofhepatocytes by IL-6 results in the synthesis of major acute...