Novel Mutations in IRF6 in Nonsyndromic Cleft Lip With or Without Cleft Palate: When Should IRF6 Mutational Screening be Done? Fernanda Sarquis Jehee, Beatriz A. Burin, K atia M. Rocha, Roseli Zechi-Ceide, Daniela F. Bueno, Luciano Brito, Josiane Souza, Gabriela Ferraz Leal, Antonio Richieri-Costa, Nivaldo Alonso, Paulo A. Otto, and Maria Rita Passos-Bueno* Centro de Estudos do Genoma Humano, D...

Acridine orange (AO) was extracted as a dye from coal tar over a hundred years ago. It has various unique biological activities and has been shown to be a useful fluorescent dye specific for DNA and RNA, a pH indicator, photosensitizer, antitumor and antimalarial drug, and detector of bacteria and parasites. It has recently been found that AO accumulates in musculoskeletal sarcomas and that aft...

Alcohol oxidase (AO) is a homo-octameric flavoenzyme which catalyzes methanol oxidation in methylotrophic yeasts. AO protein is synthesized in the cytosol and subsequently sorted to peroxisomes where the active enzyme is formed. To gain further insight in the molecular mechanisms involved in AO activation, we studied spectroscopically native AO from Hansenula polymorpha and Pichia pastoris and ...

BACKGROUND The relationship between abdominal obesity (AO) and mortality in peritoneal dialysis (PD) patients is controversial. METHODS The prevalence of AO in 84 PD patients was assessed in a cross-section manner and followed up for 9 years at a single center. AO was defined as a waist circumference (WC) of more than 90 cm in males or more than 80 cm in females. The patients were classified ...

Enhanced indexing is a hybrid fund management style that presents elements of both the active and the passive investment styles. This work presents the basic principles of enhanced indexing fund management, and proposes a methodology to generate the set of its e cient portfolios. Important operational details for practitioners are addressed, such as choosing an appropriate market risk measure, ...

BACKGROUND The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. METHODS The study population comprised 226 chronic obstructive...

AIM We undertook studies to determine the lethal dose 50 (LD50) of acridine orange (AO) using mice in order to confirm the safety of intravenous administration of AO. MATERIALS AND METHODS We used 40 mice and AO was administered once intravenously. General behavior and mortality were continuously observed for 14 days. At the end of the experiment, all animals were sacrificed for subsequent st...

A volumetric data set is a collection of data in which each data has an associated location in the three-dimensional space. In this work we review the wavelets theory and discuss the application of this technique to the visualization of volumetric data. We show the main algorithms, and discuss some implementation issues.

O problema da ordenação é sem dúvida um dos mais estudados na Ciência da Computação. No escopo da computação moderna, depois de mais de 60 anos de estudos, ainda existem muitas pesquisas que objetivam o desenvolvimento de algoritmos que solucionem uma ordenação mais rápida ou com menos recursos comparados a outros algoritmos já conhecidos. Há vários tipos de algoritmos de ordenação, alguns mais...