How do proteins fold so quickly? Some denatured proteins fold to their native structures in only microseconds, on average, implying that there is a folding "mechanism," i.e., a particular set of events by which the protein short-circuits a broader conformational search. Predicting protein structures using atomically detailed physical models is currently challenging. The most definitive proof of...

This paper explores the problem of signalling efficiency of the Session Initiation Protocol in a cellular network. We present performance metrics on SIP and compare SIP signalling efficiency with ISDN Q.931. We present recent measurement results on SIP and SigComp performance and conclude that optimisation of SIP beyond SigComp is necessary for cellular access. We suggest an optimisation proces...

It is proved that quadrature domains are ubiquitous in a very strong sense in the realm of smoothly bounded multiply connected domains in the plane. In fact, they are so dense that one might as well assume that any given smooth domain one is dealing with is a quadrature domain, and this allows access to a host of strong conditions on the classical kernel functions associated to the domain. Foll...

A method was recently proposed to estimate distances between a pair of given texts. The distance estimation appeared to be reliable enough to infer a phylogenic tree of languages, even though no error estimation has been provided. This essay reviews the method and explains its application for inferring phylogeny on a collection of heterogeneous texts. An approach for estimating the confidence o...

Using exact enumeration methods and Monte Carlo simulations, we study the phase diagram relative to the conformational transitions of a diblock copolymer in two dimensions. The polymer is made of two homogeneous strands of monomers of different species which are joined to each other at one end. We find that, depending on the values of the energy parameters in the model, there is either a first ...

Background and Aim: With the advent of problem-based learning (PBL), pioneer universities across the world started using this method to improve learning quality. One of its modifications, hybrid-PBL, incorporates a combination of PBL and traditional teaching skills. This study compared the efficacy of hybrid PBL and the conventional instruction in terms of preclinical test scores and clinical p...

objective: knowledge about the internal anatomy of the root canal and apical foramen is a critical prerequisite for root canal therapy and is necessary for the success of endodontic treatment. this study aimed to determine the distance of apical foramen from the anatomical apex and apical constriction, evaluate the deviation of apical foramen from the anatomical apex and specify the most common...