نتایج جستجو برای: aplastic
تعداد نتایج: 3920 فیلتر نتایج به سال:
Brit. med. J. (I960): Editorial: Potassium Perchlorate in Thyrotoxicosis, i, 517. (I96I): Editorial: Potassium Perchlorate and Aplastic Aniemia, i, io86. CROOKS, J., and WAYNE, E. J. (I959): Potassium Perchlorate Sensitivity, Brit. med. J., i, 1,2. ,~ (I960): Comparison of Potassium Perchlorate, Methylthiouracil and Carbimazole in Treatment of Thyrotoxicosis, Lancet, i, 401. FAWCETT, J. B., and...
BACKGROUND AND OBJECTIVES Although acquired aplastic anemia is usually a chronic disorder, a small proportion of patients with aplastic anemia was reported to recover spontaneously without specific therapy such as allogeneic bone marrow transplantation or immunosuppressive treatment. We attempted to determine the rate of spontaneous remission in the patients with AA. DESIGN AND METHODS We rev...
Paroxysmal nocturnal hemoglobinuria is caused by expansion of a hematopoietic stem cell clone with an acquired somatic mutation in the PIG-A gene. This mutation aborts the synthesis and expression of the glycosylphosphatidylinositol anchor proteins CD55 and CD59 on the surface of blood cells, thereby making them more susceptible to complement-mediated damage. A spectrum of disorders occurs in P...
I N 1961, WE REPORTED 20 cases of severe aplastic anemia in which infusions of allogenic ( homologous ) bone marrow had been used as one of the therapeutic methods.1 Seven of these patients made apparently complete recoveries; whether coincidentally or in rlationship to the marrow infusions is not clear. Since then, the use of allogeneic bone marrow infusions has been wellnigh discarded for the...
I N 1961, WE REPORTED 20 cases of severe aplastic anemia in which infusions of allogenic ( homologous ) bone marrow had been used as one of the therapeutic methods.1 Seven of these patients made apparently complete recoveries; whether coincidentally or in rlationship to the marrow infusions is not clear. Since then, the use of allogeneic bone marrow infusions has been wellnigh discarded for the...
PURPOSE OF REVIEW Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation. RECENT FINDINGS In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of hematopoietic ...
INTRODUCTION Hepatitis-associated aplastic anemia is a common syndrome in patients with bone marrow failure. However, hepatitis-associated aplastic anemia is an immune-mediated disease that does not appear to be caused by any of the known hepatitis viruses including hepatitis C virus. In addition, to the best of our knowledge there are no reported cases of patients with chronic hepatitis C viru...
BACKGROUND Although the therapeutic outcome of acquired aplastic anemia has improved markedly with the introduction of immunosuppressive therapy using antithymocyte globulin and cyclosporine, a significant proportion of patients subsequently relapse and require second-line therapy. However, detailed analyses of relapses in aplastic anemia children are limited. DESIGN AND METHODS We previously...
Various abnormalities of lymphokine production have been described in patients with aplastic anemia. To determine if abnormal production of hematopoietic growth factors could contribute to the process of aplastic anemia we studied the in vitro production of human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) by phytohemagglutinin (PHA)- and antithymocyte glo...
Sera from dogs rendered aplastic by total-body irradiation stimulate human bone marrow megakaryocyte progenitors to form megakaryocyte colonies in plasma clot cultures. In this investigation, we evaluated the effects of varying concentrations of such sera on both the mitotic and endomitotic phases of human megakaryocyte development in vitro. When low concentrations of aplastic canine sera (2.5%...
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