نتایج جستجو برای: aplastic anemia

تعداد نتایج: 56891  

Journal: :International journal of clinical and experimental pathology 2014
Aya Furuya Mitsuaki Ishida Keiko Hodohara Miyuki Yoshii Hiroko Okuno Akiko Horinouchi Ryota Nakanishi Ayumi Harada Muneo Iwai Keiko Yoshida Akiko Kagotani Takashi Yoshida Hidetoshi Okabe

It is well established that Down's syndrome exhibits a predisposition to development of leukemia, however, association between aplastic anemia and Down's syndrome is exceptional. Herein, we describe a case of aplastic anemia occurring in Down's syndrome following post-transplant lymphoproliferative disorder (PTLD) after bone marrow transplantation (BMT). A 27-year-old Japanese male with Down's ...

Journal: :Haematologica 2001
J H Lee J H Lee Y R Shin J S Lee W K Kim H S Chi C J Park K H Lee

BACKGROUND AND OBJECTIVES Although acquired aplastic anemia is usually a chronic disorder, a small proportion of patients with aplastic anemia was reported to recover spontaneously without specific therapy such as allogeneic bone marrow transplantation or immunosuppressive treatment. We attempted to determine the rate of spontaneous remission in the patients with AA. DESIGN AND METHODS We rev...

Journal: :Current opinion in hematology 2008
Neal S Young Phillip Scheinberg Rodrigo T Calado

PURPOSE OF REVIEW Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation. RECENT FINDINGS In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of hematopoietic ...

2010
Savvas Ioannou Gregorios Hatzis Ioanna Vlahadami Michael Voulgarelis

INTRODUCTION Hepatitis-associated aplastic anemia is a common syndrome in patients with bone marrow failure. However, hepatitis-associated aplastic anemia is an immune-mediated disease that does not appear to be caused by any of the known hepatitis viruses including hepatitis C virus. In addition, to the best of our knowledge there are no reported cases of patients with chronic hepatitis C viru...

2012
Meriç Kaymak Cihan Hafize Gökçe Meral Oruç Lale Olcay

Human parvovirus B19 (PV-B19) causes erythema infectiosum, hydrops fetalis, and transient aplastic crisis in immunocompromised patients with chronic hemolytic anemia, arthralgia, and chronic pure red cell aplasia [1]. It may also cause autoimmune hemolytic anemia [2] (which presents as aplastic crisis with reticulocytopenia or increased erythropoiesis with reticulocytosis) [3], autoimmune throm...

Journal: :Haematologica 2011
Takuya Kamio Etsuro Ito Akira Ohara Yoshiyuki Kosaka Masahiro Tsuchida Hiroshi Yagasaki Hideo Mugishima Hiromasa Yabe Akira Morimoto Shouichi Ohga Hideki Muramatsu Asahito Hama Takashi Kaneko Masayuki Nagasawa Atsushi Kikuta Yuko Osugi Fumio Bessho Tatsutoshi Nakahata Ichiro Tsukimoto Seiji Kojima

BACKGROUND Although the therapeutic outcome of acquired aplastic anemia has improved markedly with the introduction of immunosuppressive therapy using antithymocyte globulin and cyclosporine, a significant proportion of patients subsequently relapse and require second-line therapy. However, detailed analyses of relapses in aplastic anemia children are limited. DESIGN AND METHODS We previously...

Journal: :Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 2009
Hiroshige Nakamura Ken Miwa Yoshin Adachi Shinji Fujioka Tomohiro Haruki Yuji Taniguchi

It is very rare for both myasthenia gravis and aplastic anemia to be complicated with a thymoma. A 74-year-old female was diagnosed to have aplastic anemia with pancytopenia and systemic myasthenia gravis with severe restrictive respiratory dysfunction. Chest CT showed a 5-cm diameter thymoma. After platelets and packed red blood cells were transfused before surgery, an extended thymothymectomy...

Journal: :Annals of hepatology 2010
Nawal Al Nahdi Holly Wiesinger Heather Sutherland Eric M Yoshida

Aplastic anemia following viral hepatitis is a condition well recognized in the medical literature. Although hepatitis-associated aplastic anemia is an uncommon syndrome, there are several reports in the literature describing such cases. In these reports, aplastic anemia generally occurs following a viral infection, including parvovirus B19, but may also be idiopathic. The etiology of both the ...

Journal: :Indian pediatrics 2012
Vikramjit S Kanwar

Aplastic anemia in childhood is a difficult condition to treat, and Nair and colleagues are to be commended for their meticulous collection of single-center data over a 22year period [1]. They evaluated the efficacy of immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CSA) on 33 pediatric patients with acquired aplastic anemia in the Indian setting. Their resul...

Journal: :JPMA. The Journal of the Pakistan Medical Association 2004
M Usman S N Adil T Moatter F Bilwani S Arian M Khurshid

OBJECTIVE To study the frequency of HLA DR2 status of patients with aplastic anemia and their response to immunosuppressive therapy at a tertiary care hospital. METHODS Thirty eight consecutive patients of acquired aplastic anemia were evaluated with respect to demographic features, severity of HLA DR2 status and response outcome to immunosuppressive therapy. RESULTS The mean age of the pat...

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