Background & Aims: Retinopathy OF prematurity (ROP) is a developmental disorder of retinal vessels in premature neonates. In recent years, because of advances in the care of neonates hospitalized in equipped Intensive care units, retinopathy of prematurity has become a major cause of blindness in those who are survived. This study assessed the incidence and severity of retinopathy and related r...

OBJECTIVE To compare the efficacy and safety of Nasal intermittent positive pressure ventilation (NIPPV) and Nasal continuous positive airway pressure (nCPAP) in neonates. METHODS Standard search strategy for the Cochrane Neonatal Review Group was performed. The participants were both preterm and term infants suffering from neonatal respiratory distress syndrome or experiencing apnea of prema...

BACKGROUND Methylxanthine therapy is commonly used for apnea of prematurity but in the absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines have long-term effects on neurodevelopment and growth. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250 g to receive either caffeine or placebo until therapy for apnea of prematurity was n...

BACKGROUND Caffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects. METHODS To examine the association between the cumulative dose and duration of therapy of caffeine and osteopenia of prematurity, a retrospective cohort study was conducted including premature infants less than 31 weeks and birth weight less than 1500 g. Osteope...

Preterm newborn infants are vulnerable to a number of problems due to the immaturity of various organ systems. Apnoea of prematurity (AOP) is one such problem, thought to be due to immaturity of the cardiorespiratory centre. Although the underlying pathophysiological mechanism of AOP is not fully understood, there have been concerns that recurrent apnoeic episodes, particularly those accompanie...