Cerebral aqueduct lesions are among the most challenging to reach surgically because of their deep location and intimate association with critical neural and vascular structures. Endoscopic approaches for a third ventriculostomy or tumor removal can be considered, but these approaches disrupt the integrity of the cortex and multiple white matter fiber systems. A microsurgical anterior transcall...

Background: the large vestibular aqueduct syndrome (LVAS) is characterized by the enlargement of the vestibular aqueduct associated with sensorioneural hearing loss. The level of hearing loss varies and may be fluctuant, progressive or sudden. Vestibular symptoms may be present. The diagnosis is reached by imaging methods. Aim: To report an LVAS case. Method: a female infant was submitted to a ...

Timely generation and normal maturation of ependymal cells along the aqueduct are critical for preventing physical blockage between the third and fourth ventricles and the development of fetal non-communicating hydrocephalus. Our study identifies Yap, the downstream effector of the evolutionarily conserved Hippo pathway, as a central regulator for generating developmentally controlled ependymal...

An inscription on the supporting wall of the inverted siphon of the aqueduct of the ancient Roman city of Patara, SW Turkey, explains how the wall collapsed during an earthquake and was subsequently restored. Carbonate deposits formed inside the aqueduct channel show cyclic stable isotope changes representing 17 years of deposition. This sequence, together with the text of the inscription, allo...

A controversy exists concerning whether or not roentgenographic narrowing or nonvisualization of the vestibular aqueduct is a specific sign for Meniere's disease. Of 190 ears that were evaluated, abnormal aqueducts were seen in 42.9% of ears with Meniere's disease, 45.4% of contralateral, noninvolved ears from patients with Meniere's disease, 41.3% of ears with diseases other than Meniere's dis...

Melatonin binding in the brain of hydrocephalic H-Tx rats was examined by autoradiography. At the time of birth, hydrocephalic animals showed an abnormality in the distribution of high-affinity melatonin receptors dorsal to the cerebral aqueduct when compared to controls. Whereas newborn rats of the H-Tx strain that were unaffected by hydrocephalus had melatonin receptors in a tectal midsagitta...

A high-resolution three-dimensional Fourier transform technique and prototype bilateral dual phased-array surface coil technique was used to make inner ear structures visible on MR. Multiplanar reformatted images, parallel to the plane of the vestibular aqueduct, allowed viewing of the entire endolymphatic sac/vestibular aqueduct on one section, producing a "Christmas tree" shape. The reformati...

The majority of architectural heritage consists load-bearing masonry components made up stone units and relatively weak mortar joints, yielding potential planes for structures where tension shear failures are expected to occur. Advanced nonlinear analyses required simulate these phenomena predict the corresponding structural behavior historic constructions. In this context, paper presents a mod...