In the anterior segment of the eye, fibrin clots must be rapidly resorbed to prevent further fibrosis and scarring. The aqueous humor of patients undergoing cataract surgery was analyzed for the presence of components of the fibrinolytic cascade. In 30 patients, aqueous humor and plasma were compared for their content of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activa...

The intraocular and systemic blood pressure, height, weight, and haemoglobin were measured in 573 subjects over 60 years old from a general practice population. Intraocular pressure was positively and independently related to systemic blood pressure (P less than 0.0001) and obesity (P less than 0.01) as assessed by the ponderal index. Systolic pressure rather than diastolic or mean pressure was...

PURPOSE Many studies include elevated activity of angiotensin-converting enzyme (ACE) in serum in sarcoidosis and in ocular sarcoidosis as well, but there are only a few analyzing ACE activities in aqueous humor. The aim of this study is to illuminate the diagnostic value of ACE in aqueous humor in patients with ocular sarcoidosis. METHODS We analyzed twenty patients with ocular sarcoidosis a...

A solitary report in the literature suggests that determination of phosphohexose isomerase (PHI; glucosephosphate isomerase, EC 5.3.1.9) activity in aqueous humor and serum may be a useful adjunct in the diagnosis f retinoblastoma (1). The aqueous humor/serum PHI ratio of 20 patients with retinoblastoma was compared with that for eight “controls” having intraocular diseases other than retinobla...

IF it is granted that the aqueous humour is formed by the active transfer of solutes and solvent from the plasma to the aqueous, it follows that the rates of transfer of the various solvent or solute species and the steady-state composition of the aqueous will depend upon the electrochemical potential difference (P.D.) across its boundaries with the plasma. Alterations of the electrochemical P....

PURPOSE To develop a noninvasive test for monitoring changes in aqueous humor turnover in the mouse eye. METHODS After topical instillation of fluorescein, the rate of decay of fluorescence from aqueous humor and cornea was monitored in Black Swiss, C57 Bl6, and DBA 2J mice with a microscope equipped with epifluorescence and a charge-coupled device (CCD) camera. RESULTS The rate of decay of...

PURPOSE To detect the presence of somatostatin (SOM) in normal aqueous humor and to characterize its immunosuppressive activity. METHODS Fresh rabbit aqueous humor was assayed for SOM by competitive ELISA. Primed T cells stimulated through their T-cell receptor (TCR) were treated with SOM at concentrations that ranged the level of SOM found in normal aqueous humor. The T cells were assayed fo...

The effects of vitreous humor and some of its components on the function of rabbit corneal endothelium were investigated and compared to those of artificial and natural aqueous humor. The rate of fluid pumping across the endothelium was measured while that layer was in contact with: (1) complete medium, an artificial aqueous solution; (2) pooled rabbit aqueous humor; (3) filtered and (4) unfilt...

Adult rabbits were given single intravenous injections of 25 mg. per kilogram of sodium dicloxacillin. At intervals of time ranging from 15 minutes to 8 hours after injection, primary or secondary aqueous humor was aspirated from each eye. At the same time, a specimen of cardiac blood was withdraion. Other animals were given subconfunctival injections of 50 mg. of dicloxacillin. Aqueous humor w...

purpose : the objective of this study was to investigate the total antioxidant status (tas) and dna damage markers of serum and aqueous humor in patients with pseudoexfoliation (pex) syndrome. methods : twenty-seven cataract patients with pex and twenty-seven without pex syndrome were included in the study and groups were matched for age and gender. patients had no elevated intraocular pressure...