نتایج جستجو برای: archival biopsy samples
تعداد نتایج: 516817 فیلتر نتایج به سال:
Background. The coronary microvasculature may be abnormal even in the presence of angiographically normal epicardial arteries. Abnormalities of small coronary vessels have been invoked as a cause of angina. Methods and Results. To quantitatively evaluate the morphology of capillaries in patients with idiopathic dilated cardiomyopathy (DCM) or the syndrome of angina and small vessel disease (SVD...
Background Mutations in rat sarcoma (RAS) genes may be a mechanism of secondary resistance in epidermal growth factor receptor inhibitor-treated patients. Tumor-tissue biopsy testing has been the standard for evaluating mutational status; however, plasma testing of cell-free DNA has been shown to be a more sensitive method for detecting clonal evolution. Materials and methods Archival pre- an...
Tuberculosis and Crohn disease are granulomatous disorders affecting the intestinal tract with similar clinical manifestations and pathologic features. We evaluated the use of in situ polymerase chain reaction (PCR) using Mycobacterium tuberculosis complex-specific primers for IS 6110 to differentiate these 2 disorders in archival mucosal biopsy specimens. In situ PCR was positive in 6 of 20 tu...
Molecular strain identification of the Mycobacterium tuberculosis complex in archival tissue samples
Long-term archival of environmental samples empowers biodiversity monitoring and ecological research
Abstract Human-induced biodiversity loss and changes in community composition are major challenges of the present time, urgently calling for comprehensive biomonitoring approaches to understand system dynamics inform policy-making. In this regard, molecular methods increasingly applied. They provide tools fast high-resolution assessments can also focus on population or functional diversity. If ...
Background: Upifitamab rilsodotin (UpRi; XMT-1536) is an investigational first-in-class antibody drug conjugate (ADC) targeting NaPi2b, a sodium-dependent phosphate transport protein broadly expressed in solid tumors and approximately two-thirds of high-grade serous ovarian cancer (HGSOC) patients, with limited expression normal tissue. Efficacy safety data from Phase 1b single-agent trial UpRi...
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