BACKGROUND Salvia divinorum is a member of the Lamiaceae family and contains the psychotropic diterpene and kappa-opioid receptor agonist salvinorin-A. Originally a shamanic inebriant used by the Mexican Mazatec Indians, the plant and its preparations are becoming increasingly popular among non-traditional users. METHODS Demographic data and information on pattern of use and subjective effect...

BACKGROUND 2C-B (Nexus) is one of the most widespread novel psychoactive substances. There is limited information about its pharmacological properties, and few studies in humans concern its acute and chronic effects. 2C-B has been classified as a stimulant, hallucinogen, entactogen, and/or empathogen. OBJECTIVES To evaluate the emotional, subjective, and cardiovascular effects of 2C-B. METH...

The present study is part of a research program designed to better understand the neurochemical mechanisms underlying the abuse liability of 3,4-methylenedioxymethamphetamine (MDMA) in humans. In these studies, MDMA will be compared to prototypical dopamine (D-amphetamine) and serotonin (meta-chlorophenylpiperazine, mCPP) releasing agents on a variety of measures related to dependence. In order...

Abstract The 1960 Italian film Rocco and His Brothers (Rocco e i suoi Fratelli) is one of the greatest exemplars post-war cinema. depicts disintegration deterritorialization an immigrant family from Lucania, a southern village in Basilicata, their relocation to Milan. director film, Luchino Visconti, continuously alludes protagonist’s fascination with hometown (paese). This nostalgic wholesome ...

BACKGROUND Propofol has been widely used for an induction and/or maintenance of general anesthesia, or for sedation for various procedures. Although it has many ideal aspects, there have been several cases of drug abuse and addiction. The authors investigated whether there are abuse liable groups among the general population. METHODS We surveyed 169 patients after gastric endoscopic examinati...