BACKGROUND Quantifying the contributions that different types of information make to the accurate prediction of offending offers the prospects of improved practice and better use of resources. AIMS To quantify the contributions made by three types of information--demographic data alone, demographic and criminal record and demographic, criminal record and legal class of disorder--to the predic...

Clock drawing is recommended by medical and transportation authorities as a screening test for unsafe drivers. The objective of the present study was to assess the usefulness of different clock drawing systems as screening measures of driving performance in 122 healthy and cognitively impaired older drivers. Clock drawing was measured using four different scoring systems. Driving outcomes inclu...

OBJECTIVE Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts disease status. The goal of this work was to provide a new selection algorithm for genomic profiling. METHODS We propose a new algorithm for genomic profiling based on optimizing the area under the r...

Directional variograms, along the soil profile, can be useful and precise tool that can be used to increase the precision of the assessment of soil pollution. The detail analysis of spatial variability in the soil profile can be also an important part of the standardization of soil magnetometry as a screening method for an assessment of soil pollution related to the dust deposition. The goal of...

Table detailing the compounds released via root exudation by the plant as it develops. These were collected over a period of 3 days (7-10 days, 14-17 days, 21-24 days and 28-31 days). Compounds were detected using GC-MS. Numbers indicate the average area under the curve of three replicates, numbers in parenthesis indicate the standard deviation.

We examined two methods of generating a dose-response curve to the opioid receptor antagonist naloxone. In 15 healthy male subjects (18-25 years) plasma adrenocorticotropin (ACTH) responses to five doses of naloxone studied over 5 separate days were compared to plasma ACTH responses to five incremental doses of naloxone studied within a single session. There was a statistically significant posi...

Plasma concentration-time curves of pethidine and norpethidine were studied in 25 children allocated after operation to three groups to receive pethidine 1 mg kg-1 i.v., i.m. or rectally. Peak concentrations occurred after 5 +/- 1, 10 +/- 2, and 60 +/- 10 min, respectively, while the maximum concentrations amounted to 2800 +/- 462, 1609 +/- 367 and 531 +/- 179 nmol litre-1, respectively. The ar...

Cortisol's daytime rhythm is thought to be altered by aging and by exposure to chronic stress. However, measurement of an individual's usual cortisol rhythm is hampered by the effects of acute stressors, by differences between working days and weekends, by between-day variation in waking time and sleep duration, by variability in cortisol sampling times, and by possible variability in the timin...

BACKGROUND The intranasal (IN) administration of epinephrine could be an alternative route for anaphylaxis treatment. Although IN epinephrine absorption has been demonstrated in animals, such data in humans are still lacking. OBJECTIVE To study the pharmacokinetics of IN epinephrine absorption in humans. METHODS Each healthy adult (n = 5) was administered IN saline, IN epinephrine at variou...

Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cort...