INTRODUCTION The aim of this study was to assess the effects of albumin dialysis on hepatic encephalopathy and circulating levels of amino acids in severe alcoholic hepatitis. METHODS The study was carried out in nine patients with severe alcoholic hepatitis and four with primary biliary cirrhosis treated with the molecular adsorbent recirculating system. Besides standard liver function tests...

Aromatic amino acids function as building blocks of proteins and as precursors for secondary metabolism. To obtain plants that accumulate tryptophan (Trp) and phenylalanine (Phe), we modified the biosynthetic pathways for these amino acids in rice and dicot species. By introducing a gene encoding a feedback-insensitive anthranilate synthase (AS) alpha subunit, we successfully obtained transgeni...

Racemic aromatic β-amino acids have been kinetically resolved into (R)-β-amino acids with high enantiomeric excess (>99%) by a novel ω-TA with ca. 50% conversion.

Cation-π interactions, where protein aromatic residues supply π systems while a positive-charged portion of phospholipid head groups are the cations, have been suggested as important binding modes for peripheral membrane proteins. However, aromatic amino acids can also insert into membranes and hydrophobically interact with lipid tails. Heretofore there has been no facile way to differentiate t...

Microwave heating greatly accelerates Pd-catalyzed decarboxylative coupling of aromatic acids and aryl iodides, and allows the coupling of benzoic acids with unactivated arenes.

Benzoate competes with n-amino acids for n-amino acid oxidase and thus inhibits the activity of the oxidase (l-3). Monosubstituted benzoates, depending upon the substituent, have higher and lower affinities for the oxidase than has benzoate (2). Kojic acid, a Y-pyrone, likewise competitively inhibits the oxidase (4). The present report describes the inhibition of n-amino acid oxidase by certain...

Benzoate competes with n-amino acids for n-amino acid oxidase and thus inhibits the activity of the oxidase (l-3). Monosubstituted benzoates, depending upon the substituent, have higher and lower affinities for the oxidase than has benzoate (2). Kojic acid, a Y-pyrone, likewise competitively inhibits the oxidase (4). The present report describes the inhibition of n-amino acid oxidase by certain...

Citation: Parthasarathy A, Cross PJ, Dobson RCJ, Adams LE, Savka MA and Hudson AO (2018) A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals. Front. Mol. Biosci. 5:29. doi: 10.3389/fmolb.2018.00029 A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and A...

A ruthenium-catalyzed ortho arylation of aromatic sulfoximines with aromatic boronic acids followed by intramolecular cyclization in the presence of a palladium catalyst, providing dibenzothiazine derivatives in two consecutive steps, is described.

The transamination of aromatic l-amino acids (5-hydroxytryptophan, tryptophan, tyrosine, phenylalanine and kynurenine) was shown to be catalysed by enzyme preparations from rat small intestine. On the basis of the partial purification and characterization of these aromatic amino acid transaminases, it is suggested that rat small intestine contains several kinds of aromatic amino acid transamina...