OBJECTIVES Arterial graft spasm occasionally causes circulatory collapse immediately following coronary artery bypass graft. The aim of this study is to evaluate the efficacy of our developed materials, which were composed of milrinone (phosphodiesterase III inhibitor) or diltiazem (calcium-channel blocker), with nano-scaled fibre made of biodegradable polymer to prevent arterial spasm. METHO...

The time course of the effects of a single intravenous bolus injection of 10 mg/kg aspirin or 0.8 mg/kg F(ab')2 fragments of the monoclonal antiplatelet glycoprotein IIb/IIIa receptor antibody 7E3 [7E3-F(ab')2] on arterial occlusion, platelet aggregation, and bleeding time was studied in 30 dogs with an everted (inside out) carotid arterial segment inserted into the femoral artery. In the absen...

Injection of serotonin (5-HT) into the left atrium or ventricle activates a hypertensive chemoreflex. The primary purpose of our study was to determine the afferent pathway(s) that mediates this response. A secondary goal was to localize the receptive sites of this reflex. We measured changes in arterial pressure, reflex vascular responses in skeletal muscle and paw, and changes in renal nerve ...

We have investigated a rapidly reversible hydrophobization of therapeutic agents for improving first-pass uptake in locoregional drug therapy. This approach involves the attachment of a hydrophobic moiety to the drug by highly labile chemical linkages that rapidly hydrolyze upon injection. Hydrophobization drastically enhances cell-membrane association of the prodrug and, consequently, drug upt...

To the Editor: The injecting of illicit drugs is associated with skin and soft tissue infections (SSTIs) and vas-cular disease (1–3). These conditions include the development of cutaneous abscess and cellulitis at injection sites, from subcutaneous or intramuscular injecting, known as skin and muscle popping, and intravenous injecting (1–3). Intravenous injection is associated with phlebitis or...

introduction this paper proposes the concept of autonomous drug-encapsulated nanoparticle (adenp) as a novel non-invasive approach to prevent atherosclerosis. adenp consists of three simple units of sensor, controller (computing), and actuator. the hardware complexity of adenp is much lower than most of the nanorobots, while the performance is maintained by the synergism in the swarm architectu...