Major plasma membrane components of the tumor cell, ion channels, and integrins play crucial roles in metastasis. Glioma cells express an amiloride-sensitive nonselective cation channel composed of acid-sensing ion channel (ASIC)-1 and epithelial Na(+) channel (ENaC) α- and γ-subunits. Inhibition of this channel is associated with reduced cell migration and proliferation. Using the ASIC-1 subun...

Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory structures, and mechanical displacement generates an ASIC-dependent depolarization in some neurons. However, previous studies of mice bearing a ...

The IBM ASIC design methodology enables a product developer to fully incorporate the high-density, high-performance capabilities of the IBM CMOS technologies in the design of leading-edge products. The methodology allows the full exploitation of technology density, performance, and high testability in an ASIC design environment. The IBM ASIC design methodology builds upon years of experience wi...

Acid-sensing ion channels (ASICs) are activated by an increase in the extracellular proton concentration. There are four genes (ASIC1-4) that encode six subunits, and they are involved in diverse neuronal functions, such as mechanosensation, learning and memory, nociception, and modulation of retinal function. In this study, we characterize the ASIC currents of spiral ganglion neurons (SGNs). T...

This paper gives the Growth of the semiconductor industry has made the design of integrated circuits in daunting task. The ASIC design flow is differs the design of the clock network until late in the design of cycle when the cell placement is done and the location of the registers are known. And the clock tree estimation always based on best guess of the ASIC planner. In additional the critica...

Acid-sensing ion channels (ASICs) have been implicated in esophageal acid sensing and mechanotransduction. However, insufficient knowledge of ASIC subunit expression profile in esophageal afferent nerves hampers the understanding of their role. This knowledge is essential because ASIC subunits form heteromultimeric channels with distinct functional properties. We hypothesized that the esophagea...

An all digital interface, application specific integrated circuit (ASIC) has been developed for the control and data sampling of a quartz crystal microbalance (QCM)-based electronic nose. The ASIC is capable of measuring QCM resonant frequency between 0 – 11 MHz with a resolution of 1 Hz and +/1 Hz precision. The ASIC has been used to obtain measurements from polymer coated QCM sensors, in conj...

A technique estimated to decrease risk when developing complex digital ASICs is presented. Specification errors as well as discrepancy between the product and the specification are addressed. The CMS ECAL FENIX ASIC development [1] is presented as an example. The ASIC features a fully synthesizable and highly testable implementation of triple-redundancy. The RAM blocks are individually tested b...

Acid-sensing ion channels (ASICs) are voltage-independent proton-gated ion channels belonging to the amiloride-sensitive degenerin/epithelial Na+ channel (DEG/ENaC) family o f receptor channels. Six subunits (A SICla, lb, 2a, 2b, 3 and 4) encoded for by four genes, have been identified so far. All ASIC subunits are expressed in dorsal root ganglia (DRG) and have been implicated in physiological...