نتایج جستجو برای: aspm
تعداد نتایج: 234 فیلتر نتایج به سال:
BACKGROUND A phase II study of methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) sandwiched with radiotherapy for newly diagnosed, stage IE-IIE extranodal natural-killer/T-cell lymphoma, nasal-type (ENKTL) was conducted to explore its clinical efficacy and safety, as well as novel serum biomarkers upon anti-metabolic treatment. METHODS Four cycles of MESA sandwiched with radioth...
The ASPM (abnormal spindle-like microcephaly associated) gene has been proposed as a major determinant of cerebral cortical size among primates, including humans. Yet the specific functions of ASPM and its connection to human intelligence remain controversial. This debate is limited in part by a taxonomic focus on Old World monkeys and apes. Here we expand the comparative context of ASPM sequen...
The enlargement of cetacean brain size represents an enigmatic event in mammalian evolution, yet its genetic basis remains poorly explored. One candidate gene associated with brain size evolution is the abnormal spindle-like microcephaly associated (ASPM), as mutations in this gene cause severe reductions in the cortical size of humans. Here, we investigated the ASPM gene in representative ceta...
The anatomical basis and adaptive function of the expansion in primate brain size have long been studied; however, we are only beginning to understand the genetic basis of these evolutionary changes. Genes linked to human primary microcephaly have received much attention as they have accelerated evolutionary rates along lineages leading to humans. However, these studies focus narrowly on apes, ...
M-ary Aggregate Spread Pulse Modulation (M-ASPM) is the physical layer (PHY) modulation technique that well suited for use in low-power wide-area networks (LPWANs). Notably, M-ASPM combines high energy-per-bit efficiency, robustness, resistance to interference, and a number of other favorable technical characteristics, with spread-spectrum ability maintain capacity an uplink-focused network whi...
Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that glioblastoma patients may benefit from molecularly targeted therapies. Here, we add...
Autosomal Recessive Primary Microcephaly (MCPH) is a rare disorder of neurogenic mitosis characterized by reduced head circumference at birth with variable degree of mental retardation. In MCPH patients, brain size reduced to almost one-third of its original volume due to reduced number of generated cerebral cortical neurons during embryonic neurogensis. So far, seven genetic loci (MCPH1-7) for...
In this paper we present an overview of the M-ary Aggregate Spread Pulse Modulation (M-ASPM), and provide assessment its suitability advantages for use in low-power wide-area networks (LPWANs). Notably, M-ASPM combines high energy-per-bit efficiency, robustness, resistance to interference, a number other favorable technical characteristics, with spread-spectrum ability maintain network capacity...
Microcephaly is heterogeneous, autosomal recessive trait with reduced head circumference of at least 4 SD below age and sex means due to reduction in neuron production. The brain of microcephalic patient is architecturally normal but severe to mild mental retardation. It is rare disease affecting 2-2.5% of total population specifically in Asia and Arab where the incidence of cousin marriages is...
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