Human T lymphotropic virus type I(HTLV-I) is associated with the nonfatal neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Many clinical signs of involvement outside the central nervous system (CNS) have been described in some patients with HAM/TSP and have triggered the discovery of some HTLV-I-associated concepts in the infected individuals without sign...

discussion bladder over-distention and spontaneous bladder rupture, although very rare in ham/tsp, should be considered in a differential diagnosis of bladder rupture, especially in patients with a history of htlv1. introduction spontaneous bladder rupture is a rare manifestation of hyporeflexic bladder due to ham/tsp( human t-cell lymphotropic virus type 1 (htlv1) associated myelopathy/tropica...

HTLV type 1 and 2 are both involved in actively spreading epidemics, affecting over 15 million people worldwide. HTLV-1 has been described as the more clinically significant one, being associated with diseases such as adult T-cell leukemia and tropical spastic paraparesis. We report here a case of tropical spastic paraparesis in an HIV-positive patient who did not report any history of travel o...

Background: During the COVID-19 pandemic, besides the most prevalent respiratory and systemic symptoms, some neurological symptoms such as acute hemorrhagic necrotizing encephalopathy and myelitis associated with COVID-19 have been reported. It is suspected that COVID-19 involves different body systems via interaction with the ACE-2 (angiotensin-converting enzyme 2) receptor. As ACE2 is express...

Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-lin...

Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and laboratory tests confirmed the presence of antibodies to ...

human t-cell lymphotropic virus (htlv) types 1 and 2 belong to the oncorna group of retroviridae, a large family of viruses, grouped initially by pathogenic features, but later revised on the basis of genome structure and nucleotide sequence. htlv-i was the first discovered human retrovirus to be associated with a malignancy in 1980. the malignancy, first described by uchiyama and co-workers in...

In summary, our present system virology is confirmed current hypothesis about HAM/TSP pathogenesis with more details. It seems that Immune-dysregulation especially different cytokines expression in ACs individuals has key role in develop to HAM/TSP. In the other hand, HTLV-1 is successive intracellular pathogens which advantage from human host for hosting, replication and expansion in the human...