Catalytic asymmetric oxidation-chemistry involving heteroatom transfer from a reagent to a substrate is perhaps unparalleled in synthetic utility for the construction of enantioenriched materials.[1] Conversely, there is a significant deficiency of asymmetric two-electron oxidations that do not involve heteroatom transfer. Some potentially valuable reactions of this type include the oxidation o...

Chirality of organic molecules plays an enormous role in areas ranging from medicine to material science, yet the synthesis of such entities in one enantiomeric form is one of the most difficult challenges. The advances being made stem from the convergence of a broader understanding of theory and how structure begets function, the developments in the interface between organic and inorganic chem...

Over the last 40 years, thousands of asymmetric catalytic reactions have been invented in accord with the increasing need for enantiopure medicinal agents and the rapid advancement of the field of chemical synthesis.1 Remarkably, however, the vast majority of these enantioselective processes are derived from a small number of long-established activation modes (e.g., Lewis acid catalysis,2 σ-bon...

The metal free, single amino acid-catalyzed asymmetric desymmetrization (ADS) of meso-compounds with nitrosobenzene has been investigated using DFT. In this communication, we describe the role of electrostatic and dipole-dipole interactions in amino acid-catalyzed reactions, which has not previously been invoked in discussions of these important reactions.

An overview of asymmetric synthesis in continuous flow and microreactors is presented in this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed.