Congenitally athymic nude (nu/nu) mice and their phenotypically normal (nu/+) euthymic littermates were exposed to Coxiella burnetii administered as small-particle aerosols. After challenge, both strains of mice became infected, as characterized by rickettsemia, viable rickettsiae in the spleen, and serological conversion. The major difference noted was that euthymic animals had cleared rickett...

The aim of this research was to confirm the possible synergic effects sasam-Kyeongokgo (SKOG) on anti-tumor activity gefitinib using athymic nude mice bearing human non-small-cell lung squamous cell carcinoma (NSCLC) NCI-H520 line after continuous oral combination treatment provided daily for 35 days within a timeframe 5 min, as developing process novel preventive and therapeutic regimes variou...

Transfer of anti-Sindbis virus serum, obtained from peripherally inoculated donors, protected mice from an otherwise fatal intracerebral infection with neuroadapted Sindbis virus (NSV). F(ab)'2 preparations of serum were not protective, indicating that the Fc piece of immunoglobulin G was important. Complement-depleted animals were protected with anti-NSV serum, ruling out as essential the comp...

• PSGL-1 protein is frequently expressed at the surface of malignant T cells. Enforced expression promotes cell tumorigenesis in mice. accelerates dissemination from tumors to several organs. expansion kidneys and lungs. P-selectin glycoprotein ligand-1 (PSGL-1) a membrane-bound lymphoid myeloid It ligand P-, E- L-selectin involved trafficking homing tissues, among other functions. has been imp...

The athymic nude mouse is often used to grow tumors for in vivo oncology research, including the identification of anticancer drugs, whereas wild-type mice are usually used to assess the pharmacokinetics (PK) of new chemical entities. The relationship between PK and pharmacodynamics (PD) provides useful mechanistic information and helps guide of the clinical regimen. The aim of this study was t...