Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

Heavy-metal ions are common pollutants in wastewater and thus attracting considerable attention. Herein, an eco-friendly biodegradable adsorbent, iminodisuccinic acid (IDS) modified attapulgite (ATP) is prepared by graft-polymerization to reduce Cu(II) water, referred as IDS-ATP. The equilibrium adsorption capacity of IDS-ATP for increased 329.5% 272% compared with raw ATP non-degradable chelat...

Abstract Tripartite efflux pumps built around ATP-binding cassette (ABC) transporters are membrane protein machineries that perform vectorial export of a large variety drugs and virulence factors from Gram negative bacteria, using ATP-hydrolysis as energy source. Determining the number ATP molecules consumed per transport cycle is essential to understanding efficiency substrate transport. Using...

in order to perform breeding programs and improve production of native chickens, preserving genetic diversity in different areas of iran is important due to the reduced available population. genome sequencing is considered the most functional approach to determine the phylogeny relation between close populations. the aim of the present study was the evaluation of the phylogeny and genetic nucle...

In the skin, adenosine triphosphate (ATP) is released from various types of cells by environmental stimuli via nonlytic mechanisms, cell damage, or acute death. Because ATP a potent inducer skin inflammation, it has to be promptly hydrolyzed for achieve homeostasis. Of note, activates mast (MCs) through P2X7R, leading enhanced inflammation. However, MC involvement in impairment inflammation hyd...

The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from islets Langerhans. Glucose-stimulated insulin (GSIS) by pancreatic β -cell is main mechanism for reducing elevated plasma glucose. Here we present systematic modeling workflow development kinetic pathway models using Systems Biology Markup Language (SBML). Steps include retrieval informa...