Background: Cu(atsm) [(diacetylbis(N(4)methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1 mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte and microglial activation also resulted from treatment. Conclusion: Cu(atsm) is neuroprotective in this model even when treatment beg...

Introduction: [Cu]diacetyl-bis(N-methylthiosemicarbazone) ([Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced via the Zn(p,n)Cu nuclear reaction (30 MeV protons at 180 μA) was used for the p...

The goal of this work was to study the efficacy of the positron emission tomography (PET) tracers 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) and in monitoring placental and fetal functional response to acute hyperoxia in late-term pregnant mice subjected to experimentally induced chronic hypoxia. E15 mice were maintained at 12% insp...

Most cancer deaths are a consequence of resistance to conventional chemotherapy and radiation therapy. This may be attributable to unique phenotypic characteristics of solid tumors. We have exploited two welldescribed characteristics of solid tumors commonly associated with treatment failure, high glucose use and hypoxia, to design a unique therapy based on the selective accumulation of two cyt...

introduction: [61cu]diacetyl-bis(n4-methylthiosemicarbazone) ([61cu]atsm) is a well-established hypoxia imaging tracer with simple production and significant specifity. in this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. methods: [61cu]atsm was prepared using atsm ligand and [61cu]cuoac followed by i.v. administration and imaging studi...

BACKGROUND We designed a hypoxia-imaging modality to detect ischemia of the gastric conduit after esophagectomy. MATERIALS AND METHODS A rat esophagectomy model was created using 12-16-week-old, 300-350 g male Sprague-Dawley rats. In the operation group (n=6), partial gastric devascularization was performed by ligating the left gastric artery and the short gastric arteries and an esophagogast...

INTRODUCTION Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between...

background: gts, ptsm and atsm are bis-thiosemicarbazone ligands used in the preparation of copper radiopharmaceuticals. chemical structure of these materials indicates that they should have radio-protective effects. objective: to study the radio-protective effects of gts, ptsm and atsm. methods: this study has focused on radio-protective effects of these compounds at different doses (20, 40 an...

BACKGROUND Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[(18) F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N(4))-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor mod...