Autoimmune liver diseases are chronic liver disease with similar clinical features to viral and non-autoimmune liver disorders but with distinct sero-autoimmunologic features. In developed countries, it accounts for about 20% of all liver transplantations in the USA. Most studies on liver disease in Nigeria centred on viral or alcohol aetiology with complete absence of data on autoimmune liver ...

CONTEXT The PNPLA3 I148M variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. The I148M variant is associated with many chronic liver diseases. However, its potential association with inflammatory and autoimmune liver diseases has not been established. EVIDENCE ACQUISITION We systemical...

Patients with autoimmune urticaria show a higher rate of seropositivity for other autoantibodies and often have a history of autoimmune conditions. They also tend to have more severe symptoms and to have a poor response to conventional antihistamine treatment. Autoimmune hepatitis is a chronic inflammatory disorder in which progressive liver injury is thought to be the result of a T-cell-mediat...

Inflammatory neuropathies may be due to infection (with a specific casual agent identified) including Lyme disease, HIV, Leprosy, Herpes Zoster, Hepatitis B & C. The other group of are Autoimmune or possibly infectious (but with no specific causal infectious agent identified) including sarcoidosis, Guillain-Barre syndrome/ acute inflammatory demyelinating polyneuropathy ( AIDP), chronic in...

Type I interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The development of autoimmune hepatitis is a well recognized complication of treatment with alpha IFN in patients with chronic viral hepatitis. Yet, the occurrence in patients under treatment with beta IFN for other indications is controversial and its occurrence often underestimated....

aim : we described two case reports of aih/ssc overlap syndrome and reviewed literatures regarding this issue.   background : aih is a chronic hepatitis of unknown aetiology characterized by continuing hepatocellular necrosis and inflammation. aih overlap syndromes have been reported with other autoimmune diseases. patients and methods : according to the classification criteria for ssc, we cond...

Hepatitis C virus infection and diabetes mellitus are two major public health problems worldwide and the burden of these diseases is expected to increase in the near future. Hepatitis C virus is associated to autoimmune disorders of several organs (e.g. thyroid and kidney) and has recently been reported to be associated also to metabolic disorders including type 2 diabetes mellitus. Biologicall...

There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms. Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis. Both patients reported black cohosh...

background: there are only a very small number of reports which discuss subtype, sex distribution, clinical features and laboratory characteristics of autoimmune hepatitis in children. the aim of this study was both to define the clinical features, biochemical and histological findings and also to determine the age and sex related distribution of autoimmune hepatitis (aih). materials and method...

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown etiology associated with circulating autoantibodies and hypergammaglobulinemia. Patients with AIH occasionally suffer from other autoimmune diseases. Similarly, systemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organs and coexisting with other autoimmune diseases. Although the liver is no...