Anti-Müllerian hormone receptor, type II (AMHR2), is a differentiation protein expressed in 90% of primary epithelial ovarian carcinomas (EOCs), the most deadly gynecologic malignancy. We propose that AMHR2 may serve as a useful target for vaccination against EOC. To this end, we generated the recombinant 399-amino acid cytoplasmic domain of mouse AMHR2 (AMHR2-CD) and tested its efficacy as a v...

Neeru Gupta*, Chhaya Gupta Department of Pathology, Sri Balaji Action Medical Institute, Paschim vihar, New Delhi, India Xanthogranulomatous oophritis is an unusual chronic inflammatory condition which clinically presents as a mass like lesion in the pelvic cavity. It invades the surrounding tissue and thus mimics like a tumor. Patients with xanthogranulomatous oophoritis presents with lower ab...

Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules. When CD4+ cell suspensions prepared from BALB/c nu/+ mice lymph nodes and spleens were depleted of CD25+ cells by specific mAb and C, and then inoculated into BALB/c athymic nude (nu/nu) mice, all recipients spontaneously developed hi...

A 58 year old woman presented with lower abdominal pain and diarrhoea leading to a right hemicolectomy for Crohn's disease. She remained asymptomatic for 23 years until recurrence of disease necessitated resection of 17 cm of ileum. Five years later she developed multiple short Crohn's strictures with fistulae and abscesses into the pelvis. Two areas of ileum measuring 10 cm and 29 cm were exci...

Systemic lupus erythematosus (SLE) is a chronic autoimmune systemic disease that mainly affects women of reproductive age. Emerging data from recent molecular studies show us that estrogen hormone plays a central role in the development of this disease. By acting via its cognate receptors ERα and ERβ expressed on immune cells, estrogen can modulate immune function in both the innate and adaptiv...