The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in first- and second-degree relatives were compared in 279 in...

The aim of this study was to determine the risk of myasthenia gravis (MG) in patients with allergic or autoimmune thyroid disease in a large cohort representing 99% of the population in Taiwan. Data from the Taiwan National Health Insurance Database were used to conduct retrospective analyses. The study comprised 1689 adult patients with MG who were 4-fold frequency matched to those without MG ...

It has long been known that there is a close relationship between pregnancy and the thyroid gland-iodine insufficiency, goitre development, and abnormal thyroid function are common during pregnancy. Autoimmune thyroid disease and thyrotoxicosis may also affect pregnant women, and their management requires the understanding of the interaction between the neuroendocrine and immune systems. In thi...

Marked alterations in the level of circulating thyroid hormone frequently induce cutaneous changes. Such visible sequelae of hyperthyroidism or hypothyroidism can be among the first manilestationsot thyroid dysfunction. The etiology of such thyroid dysfunction is frequently attributable to autoimmune thyroid disease, as manifested by Graves' disease (diffuse toxic goiter) or Hashimoto's thyroid...

Autoimmune diseases are a group of disorders in which the immune system dysfunctions and attacks host tissues. Although the pathogenesis of autoimmune thyroid disease has not been elucidated, there are several factors that have been associated with the disorder. Factors include genetic predisposition, nutrient deficiencies, use of certain medications affecting thyroid function, and environmenta...

Autoimmune thyroid disease (AITD) is a disease in which the body interprets the thyroid glands and its hormone products triiodothyronine (T3), thyroxine (T4) and thyroidstimulating hormone (TSH) as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it. It presents with hypothyroidism (low production of thyroid hormone) or hyperthyroidism (excessi...