Two patients with agranulocytosis associated with diphenylhydantoin (DPH) therapy and clinical data suggesting suppression of granulopoiesis were investigated using in vitro culture techniques for committed granulocyte I macrophage precursors. Addition of DPH to cultures containing the patients’ sara resulted in significant suppression of colony growth. Extensive studies on the acute serum from...

Background and purpose Autologous conditioned serum (ACS) is a disease-modifying drug for treatment of osteoarthritis (OA). To establish that the autologous serum has protective effect on chondropathy. The aim of this study was evaluate the efficacy of ACS as osteoarthritis therapy. Methods Literature review for intraarticular ACS somministration in human study. Results and interpretation We an...

Two patients with agranulocytosis associated with diphenylhydantoin (DPH) therapy and clinical data suggesting suppression of granulopoiesis were investigated using in vitro culture techniques for committed granulocyte I macrophage precursors. Addition of DPH to cultures containing the patients’ sara resulted in significant suppression of colony growth. Extensive studies on the acute serum from...

background: stearic acid is known as a potent anti-inflammatory lipid. this fatty acid has profound and diverse effects on liver metabolism. the aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (apap)-induced liver damage. methods: wistar rats were randomly assigned to 10-day treatment. stearic acid was administe...

We used an RIA and inhibition of enzyme activity to monitor the changes in mass and catalytic concentrations of the aspartate aminotransferase (EC 2.6.1.1;AST) isoenzymes in serum after myocardial infarction. Cytosolic (c-AST) and mitochondrial (m-AST) forms of AST were present in sera from all 38 of our patients. Although the immunological and catalytic concentrations of both isoenzymes correl...

Previous studies showed that the Infratonic Stochastic Resonance (SR) therapy increases race performance on standard-bred horses and decreases the risk of inflammation and muscle injury. In the present study we continued investigating the benefits of this therapy on standard-bred racehorses. We expand the research to the analysis of the hyaluronic acid levels and the quality of the synovial flu...

Background: Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. Methods: Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administe...