INTRODUCTION ................ ................................ 483 DISCOVERY OF REOVIRUSES .............................................. 483 STRUCTURE OF THE REOVIRUS PARTICLE .................. ............. 484 REOVIRUS GENOME ................................................ 484 PROTEINS OF REOVIRUS ................................................ 486 INFORMATION CONTENT OF THE 10 REOVIRUS G...

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

Oncolytic reovirus induces innate immune responses, which contribute to the antitumor activity of reovirus, following in vivo application. Reovirus-induced innate immune responses have been relatively well characterized in immune cells and mouse embryonic fibroblasts cells; however, the mechanisms and profiles of reovirus-induced innate immune responses in human tumor cells have not been well u...