Aggregatibacter actinomycetemcomitans invades periodontal pocket epithelium and is therefore difficult to eliminate by periodontal scaling and root planing. It is susceptible to azithromycin, which is taken up by many types of mammalian cells. This led us to hypothesize that azithromycin accumulation by gingival epithelium could enhance the killing of intraepithelial A. actinomycetemcomitans. [...

Background. The use of azithromycin for its anti-inflammatory effect in chronic obstructive pulmonary disease, cystic fibrosis, and lung transplant recipients has increased significantly. Recently published data cited a rise in cardiovascular death in patients with azithromycin compared to other antibacterial agents. In response, the FDA released warnings regarding prescribing azithromycin in c...

Authors: Uzun S, Djamin RS, Kluytmans JAJW, et al. Lancet Respir Med 2014; 2: 361–368 Summary: This study represents a significant development in the use of long-term azithromycin maintenance treatment in a subgroup of patients with chronic obstructive pulmonary disease (COPD). Patients with .3 exacerbations in the preceding year were randomised to receive thrice-weekly placebo or azithromycin ...

Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin ...

Azithromycin differs chemically from erythromycin by having an extra positive charge created by the presence of a methyl-substituted nitrogen in the 15-membered macrolide ring. This results in substantially increased potency against Gram-negative bacteria. Therefore, the possibility was considered that azithromycin was taken across the outer membrane of Escherichia coli by the self-promoted upt...

Streptococcus suis (S. suis) caused serious disease symptoms in humans and pigs. S. suis is able to form thick biofilms and this increases the difficulty of treatment. After growth with 1/2 minimal inhibitory concentration (MIC) of azithromycin, 1/4 MIC of azithromycin, or 1/8 MIC of azithromycin, biofilm formation of S. suis dose-dependently decreased in the present study. Furthermore, scannin...

23 The adverse effects of azithromycin on the treatment of patients with chronic lung 24 diseases (CLD) were evaluated in the present study. 25 MEDLINE, and other databases were searched for relevant articles till August 2013. 26 Randomized controlled trials enrolled patients with chronic lung diseases who 27 received long-term azithromycin treatment were selected and data on microbiological 28...

There is considerable interest in the use of azithromycin for the treatment of lung disease in patients with cystic fibrosis (CF). Although its mechanism of action as an inhibitor of bacterial protein synthesis has been well-established, it is less clear how azithromycin ameliorates the lung disease associated with Pseudomonas aeruginosa, which is considered to be resistant to the drug. We test...

The dicationic macrolide antibiotic azithromycin inhibits the uptake of horseradish peroxidase (HRP) by fluid-phase pinocytosis in fibroblasts in a time- and concentration-dependent fashion without affecting its decay (regurgitation and/or degradation). The azithromycin effect is additive to that of nocodazole, known to impair endocytic uptake and transport of solutes along the endocytic pathwa...