AIMS The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN. METHODS AND RESULTS We performed a prospective, randomized trial between March 2005 and December 2009, including 258 consecutive patients with renal insufficie...

The objective of the study was to obtain the pharmacokinetic data of two controlled release formulations of (75 mg) indomethacin and to compare the relative bioavailability of the test formulation (product B cetostearyl alcohol microspheres) with standard formulation (product A–MicrocidSR 75 mg capsule). A single dose randomized (4×2) complete cross over study of the indomethacin (75 mg) was ca...

Here for the first time, we investigated the cytotoxic effects of the chitosan extracted from the Persian Gulf Chiton shell (Acanthopleura vaillantii) on liver cancer cell line (HepG2). Chitosan extraction was implemented following this method: chitin was produced by demineralization and deproteinization procedure, and the extracted chitin was converted into soluble chitosan using deacetylation...

OBJECTIVES The efficacy of high dose furosemide as a continuous infusion was compared with a bolus injection of equal dose in patients with severe heart failure. BACKGROUND The delivery rate of furosemide into the nephron has been proved to be a determinant of diuretic efficacy in healthy volunteers. METHODS In a randomized crossover study we compared the efficacy of a continuous infusion o...

BACKGROUND Emerging evidence suggests that angiogenic and pro-inflammatory cytokine leptin might be implicated in ocular neovascularization. However, the potential of inhibiting leptin function in ophthalmic cells has never been explored. Here we assessed mitogenic, angiogenic, and signaling leptin activities in retinal and corneal endothelial cells and examined the capability of a specific lep...

the aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (lf) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. total of 12 subjects were divided into two groups “a” (healthy volunteers) and “b” (typhoid patients). single oral dose of lf 500 mg was given and 5 ...

The limited sampling model (LSM) offers a means of estimating the area under the concentration-time curve (AUC) from only two timed plasma concentrations. In this study, pharmacokinetic profiles were simulated for 23 patients treated with amonafide, using each patient's individual pharmacokinetic parameters. Data were simulated for a dose of 250 mg/m2 administered over 1 h. The initial 15 patie...

PURPOSE The survival of adults with acute leukemias remains unsatisfactory and requires new treatment approaches. Flavopiridol modulates cell cycle progression, inhibits transcription, and induces apoptosis. We designed an in vitro model of timed sequential therapy for acute leukemia to determine whether flavopiridol can: (a). trigger apoptosis in fresh acute leukemia; and (b). recruit survivin...

OBJECTIVE To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji (CV 3) and Guanyuan (CV 4) for preventing dysuria after internal fixation of lower limb fractures. METHODS Sixty patients conforming to the inclusion standards were randomly divided into a treatment group (n = 30) and a control group (n = 30). Fuzi-cake-separated moxibustion was performed at Guanyua...

OBJECTIVE Inhibin-B (Inh-B) is produced by Sertoli cells and controls Follicle Stimulating Hormone (FSH) secretion through a negative feedback mechanism. The primary aim of this study was to compare Iotanh-B with FSH as predictors of the recovery of sperm in testicular fine needle aspirate in men with azoospermia. DESIGN In 51 men with azoospermia basal values of Luteinizing Hormone (LH), FSH...