نتایج جستجو برای: b acute lymphoblastic leukemia
تعداد نتایج: 1388968 فیلتر نتایج به سال:
background obesity is a medical problem in survivors of childhood acute lymphoblastic leukemia. obesity is associated with many complications, so it is important to investigate the respective etiology. leptin is a protein synthesized in the fatty tissue and is effective in the control of obesity. survey of leptin in acute lymphoblastic leukemia (all) survivors could be helpful in controlling ob...
background: dysregulation of wnt signaling has been reported in many malignancies. objective: this study was conducted to investigate the expression pattern of 14 members of the wnt gene family in different immunophenotypic subtypes of all. methods: semi-quantitative rt-pcr was performed on samples from 71 all patients and 36 age-matched healthy individuals. the all patients were categorized in...
t cell acute lymphoblastic leukemia (all) is an invasive disease with a higher incidence in children and adolescents. in terms of immunophenotype, t-all is positive for cd2, cd7, cd34 and hla-dr, and the level of these markers is increased with increasing age. in addition, the myeloid markers (cd13, cd33) are sometimes expressed in t-all. in this study, we introduce a rare case of a 28-year-old...
Aim: Leukemia targets are one of the most common childhood malignancies. Epstein-Barr virus is a tumorigenic virus of the herpes family of viruses and causes primary infection in young children. The aim of this study was to evaluate the increase in NFKB expression following EBV virus and its contribution to the half-life of EBV-positive acute lymphoblastic leukemia patients. Materials and Meth...
B-cell acute lymphoblastic leukemia is the most common type of pediatric leukemia. Despite improved remission rates, current treatment regimens for pediatric B-cell acute lymphoblastic leukemia are often associated with adverse effects and central nervous system relapse, necessitating more effective and safer agents. Bafilomycin A1 is an inhibitor of vacuolar H(+)-ATPase that is frequently used...
1. Reiter A, Schrappe M, Luwdig WD, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 1994; 84:3122-33. 2. Wan JH, Trainor KJ, Brisco MJ, Morley AA. Monoclonality in B-cell lymphoma detected in paraffin wax embedded using the polymerase chain reaction. J Clin Pathol 1990; 43:888-90. 3. Brisco...
Chromosome abnormalities that usually define high-risk acute lymphoblastic leukemia are the t(9;22)/ breakpoint cluster region protein-Abelson murine leukemia viral oncogene homolog 1, hypodiploid with < 44 chromosomes and 11q23/ myeloid/lymphoid leukemia gene rearrangements. The spectrum of acute lymphoblastic leukemia genetic abnormalities is nevertheless rapidly expanding. Therefore, newly d...
conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the imp...
BACKGROUND MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic leukemia. DESIGN AND METHODS Expression levels of 397 microRNA (including novel microRNA) were measured by quantitative real-time polymerase chain...
The transcription factor Sox4 plays an indispensable role in the development of early progenitor B cells from hematopoietic stem cells. However, its role in B-cell acute lymphoblastic leukemia, a malignant counterpart of normal progenitor B cells, is not fully understood. Here we show that SOX4 is highly expressed in human acute lymphoblastic leukemia cells. To systematically study the function...
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