We propose a simple approach, the multiplicative background correction, to solve a perplexing problem in spotted microarray data analysis: correcting the foreground intensities for the background noise, especially for spots with genes that are weakly expressed or not at all. The conventional approach, the additive background correction, directly subtracts the background intensities from foregro...

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MOTIVATION Advances in technology have made different microarray platforms available. Among the many, Illumina BeadArrays are relatively new and have captured significant market share. With BeadArray technology, high data quality is generated from low sample input at reduced cost. However, the analysis methods for Illumina BeadArrays are far behind those for Affymetrix oligonucleotide arrays, a...

MOTIVATION Microarray data must be background corrected to remove the effects of non-specific binding or spatial heterogeneity across the array, but this practice typically causes other problems such as negative corrected intensities and high variability of low intensity log-ratios. Different estimators of background, and various model-based processing methods, are compared in this study in sea...

to investigate the effect of preprocessing techniques including contrast enhancement and illumination correction on retinal imagequality, a comparative study was carried out. we studied and implemented a few illumination correction and contrast enhancementtechniques on color retinal images to find out the best technique for optimum image enhancement. to compare and choose thebest illumination c...

MOTIVATION High-throughput cell-based phenotypic screening has become an increasingly important technology for discovering new drug targets and assigning gene functions. Such experiments use hundreds of 96-well or 384-well plates, to cover whole-genome RNAi collections and/or chemical compound files, and often collect measurements that are sensitive to spatial background noise whose patterns ca...

The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-wide association studies, however, this array-based measurement of DNA methylation is subject to measurement variation. Appropriate data preprocessing to remove background noise is important for detecting the small changes that may be associated with disease. We developed a novel background correction method, ENmix,...

This paper describes a technique for digital error correction in pipelined analog-digital converters. It makes use of a slow, high resolution ADC in conjunction with an LMS algorithm to perform error correction in the background during normal conversion. The algorithm will be shown to correct for errors due to capacitor ratio mismatch, finite amplifier gain and charge injection within the same ...