Urinary tract infections are most commonly caused by uropathogenic strains of Escherichia coli (UPEC), which invade superficial bladder epithelial cells via a type 1 pilus-dependent mechanism. Inside these epithelial cells, UPEC organisms multiply to high numbers to form intracellular bacterial communities, allowing them to avoid immune detection. Bladder epithelial cells produce interleukin-6 ...

BACKGROUND Urinary tract infections (UTIs) are one of the most common bacterial infections and are predominantly caused by uropathogenic Escherichia coli (UPEC). While UTIs are typically considered extracellular infections, it has been recently demonstrated that UPEC bind to, invade, and replicate within the murine bladder urothelium to form intracellular bacterial communities (IBCs). These IBC...

Recurrent urinary tract infections (RUTI) occur in 10-15 % of women reproductive age and 20 menopausal have an extremely negative impact on quality life. Urinary (UTIs) account for about 40 all hospital-acquired 50% bacterial resulting long-term hospitalisation. In Russia, 26-36 million cases acute cystitis are reported each year. Because its high prevalence, UTI is economic problem. Clinically...

Chaperone-usher pathway pili are a widespread family of extracellular, Gram-negative bacterial fibers with important roles in bacterial pathogenesis. Type 1 pili are important virulence factors in uropathogenic Escherichia coli (UPEC), which cause the majority of urinary tract infections (UTI). FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and murine bladder...

Uropathogenic Escherichia coli (UPEC) utilizes a complex community-based developmental pathway for growth within superficial epithelial cells of the bladder during cystitis. Extracellular DNA (eDNA) is a common matrix component of organized bacterial communities. Integration host factor (IHF) is a heterodimeric protein that binds to double-stranded DNA and produces a hairpin bend. IHF-dependent...

INTRODUCTION: Dysuria is a painful urination combined with its frequency and/or difficulty. observed in many urological diseases and one of the most common reasons for treatment cause.
 AIM: The aim study to identify etiological factors dysuria women evaluate personalized approach their treatment.
 MATERIALS AND METHODS: We analyzed data 368 chronical cystitis. inclusion criteria were...

During epithelial infections, pathogenic bacteria employ an array of strategies to attenuate and evade host immune responses, including the influx of polymorphonuclear leukocytes (PMN; neutrophils). Among the most common bacterial infections in humans are those of the urinary tract, caused chiefly by uropathogenic Escherichia coli (UPEC). During the establishment of bacterial cystitis, UPEC sup...