Extracts of acetone powders of Flavobacterium heparinum which have been adapted to heparin catalyze a rather extensive degradation of this mucopolysaccharide. This ‘Lheparinase” activity is due to the presence in the extract of a sulfamidase, a sulfesterase, and at least one glycosidase (1, 2). Such extracts also catalyze the hydrolysis of hyaluronic acid and chondroitin sulfate. This paper com...